The Portuguese inquiry into the disappearance of Madeleine McCann has been reopened amid new leads in the case.
Detectives have ruled out the key sighting that underpinned the original Madeleine McCann investigation and adopted a new focus in the hunt.
On the day she disappeared Madeleine McCann asked her parents a question: “Why didn’t you come when Sean and I cried last night?”
Detective Chief Inspector Andy Redwood, who is investigating the disappearance of Madeleine McCann, on the BBC's Crimewatch programme:
The media appeals produced a fantastic response from the public in all three countries with a total of 3,500 calls and messages in the UK, 850 to Germany, and 650 in Holland.
Lots of people have called to say they were in Praia da Luz at the time. All of this information has obviously produced a very large volume of work for the Operation Grange team to work through.
I have been in Faro this week working with police colleagues, and I know the appeal generated a large number of calls to the Portuguese police also.
I'd like to thank the media and the public for their continued assistance in this challenging enquiry.
A senior detective investigating the disappearance of Madeleine McCann has thanked the public for thousands of messages received in the wake of recent television appeals.
Detective Chief Inspector Andy Redwood said several holidaymakers who were in Praia da Luz, Portugal in 2007 when the little girl vanished had made contact with his team.
British police launched their own investigation into Madeleine's disappearance earlier this year, called Operation Grange, and recently made renewed appeals for information on television in the UK, Holland and Germany.
British and Portuguese police should join together as one team in their investigations into the disappearance of Madeleine McCann, the Metropolitan Police Commissioner has said.
Currently Scotland Yard is running its own inquiry into what happened to the little girl, who vanished while holidaying with her parents in Praia da Luz in 2007, while the Portuguese authorities have their own investigation.
Sir Bernard Hogan-Howe said: "One thing we'd like to see in the future is a joint investigation team which comes under the European community. It is a possibility legally, and we're working together at a political level, and at a police and judicial level, to see how we can construct that.
"There are two separate inquiries with a different focus - we've got one particular set of lines of inquiry and they have a different one. But it's important that we work together on what is clearly a common problem.
"It's a formal arrangement, it allows officers from each country to work in the other country, it gives them powers associated with that, and it's an efficient way of doing it.
"If you're not careful, you end up doing things on an ad-hoc basis, and for us it would be better to have that type of arrangement. So that's what we're trying to get agreement between the two governments and the two police services."
A Prison Service spokesman said:
An investigation has taken place at HMP Wandsworth and appropriate disciplinary action has been taken following an incident concerning a number of prison officers outside of working hours and away from the prison.
Until the disciplinary process is completed we are unable to comment further.
An inquiry has been launched following claims that a group of prison officers went on a night out wearing T-shirts emblazoned with the words "We have Madeleine McCann".
Photographs of the staff were posted on Facebook for two months before their bosses at Wandsworth Prison in south London were alerted, the Metro said.
The incident led to a prison officer being sacked and four others disciplined, according to the report.
The McCanns have described new reports about a man Portuguese police allegedly suspect kidnapped Madeleine as "pure speculation".
The 40-year-old had been fired from the Ocean Club holiday complex in Praia de Luz where the McCanns were staying when their daughter disappeared on May 3, 2007, and may have been seeking revenge, Portuguese daily Correio da Manha said.
He died in a tractor accident in 2009 but police have interviewed his widow as part of their new investigation, according to the newspaper.
Clarence Mitchell, who represents Kate and Gerry McCann, said: "We are aware of reports in the Portuguese press.
"They are pure speculation and the McCanns are not going to give a running commentary on every new report."
ITV News understands that Portuguese Police are investigating a new lead in the search for Madeleine McCann. They now believe she may have been taken by a disgruntled former hotel worker. The man they suspect, died four years ago.
ITV News Europe Correspondent Emma Murphy reports:
The former hotel employee who Portuguese police are investigating over Madeleine McCann's kidnapping could have snatched her out of revenge after being sacked, newspaper Correio da Manha reported.
The 40-year-old died in a tractor accident in 2009 - two years after Madeleine went missing - and police have already questioned his widow, the paper said.
He was identified as the Portuguese police's main suspect after they reportedly discovered from tests on his mobile phone that he was near the holiday apartment in Praia de Luz when she went missing.
The flat the McCanns were staying in is a 15 minute drive to the town of Lagos where the suspect was living at the time after he stopped working at the Ocean Club.
Portuguese police are now said to be searching for her body in the belief he may have killed her, the paper adds.
A source close to Madeleine McCann's parents has told ITV News that they are "aware" Portuguese police are investigating the possibility a former employee at the hotel in Praia de Luz where the family were staying may have kidnapped her.
It is understood the 40-year-old man died in a tractor accident in 2009 - two years after Madeleine disappeared.