Madeleine McCann detectives identified at least "a handful of people of interest" as part of a review of the case.
A timeline of some of the key events since Madeleine McCann disappeared in 2007 following reports suspects have been identified.
A letter received by Scotland Yard in 1998 claiming the DJ was a paedophile was classed as "sensitive", hiding it from other investigators.
A former Met Police firearms officer has commended the police for the way they dealt with the attack in Woolwich on Wednesday.
Speaking to Daybreak, Roger Gray said: "They've responded in exactly the way that they have been trained to do, they responded in a very, very measured way in the face of a very real and imminent threat, which we haven't seen a parallel of."
He added: "They should be commended for being that measured in their response in these circumstances."
Our investigative review is ongoing and we are encouraged by the progress we are making. We are reviewing a significant number of documents and continue to identify potential lines of inquiry.
We can confirm that as part of this process we have identified a number of persons of interest, but any suggestion that the MPS is asking the Portuguese Police to make arrests in connection with this inquiry is entirely inaccurate.
– A Metropolitan Police spokesman
We are in regular contact with Kate and Gerry McCann and they are kept fully updated on the progress of our work.
We also continue to work closely with the Portuguese Police and are actively considering our next steps.
Clarence Mitchell, spokesman for the Kate and Gerry McCann, said: "Kate and Gerry remain very, very pleased with the work that Scotland Yard are doing and have been encouraged by Operation Grange from the day it began.
"Beyond that, they simply will not comment on what are police operational matters."
Detective Chief Superintendent Hamish Campbell, who led a Metropolitan Police review of the six-year-old case, retired today as head of Scotland Yard’s homicide and serious crime command.
Speaking earlier this month, on the sixth anniversary of Madeleine McCann's disappearance, her parents Kate and Gerry, said they had not given up hope of finding their daughter.
Speaking on Daybreak, the couple said they have not lost hope that their daughter would be found and continue to campaign tirelessly for information on her whereabouts.
They believe the involvement of the Metropolitan Police now meant the hunt for their daughter was escalating, rather than grinding to a halt.
Mrs McCann said: "The search is very much ongoing. Nothing is slowing down, if anything I feel it's escalating with the work of the Met.
"And again it's just be vigilant, please still take your posters on holiday and don't forget about her, she's still missing.
"We haven't lost hope, our hope isn't any less than it was after the first 24, 48 hours."
Detectives reviewing the disappearance of Madeleine McCann have identified at least "a handful of people of interest" in connection with the case, Scotland Yard has confirmed.
– Detective Chief Superintendent Hamish Campbell
The purpose of the review was to look at the case with fresh eyes and there is always real benefit in doing so. The review has further identified both investigative and forensic opportunities to support the Portuguese.
There is more than a handful of people of interest which could be explored further if only to be eliminated.
The key things are to investigate the case and our work is happening to support the Portuguese.
A number of new potential suspects in the Madeleine McCann disappearance case have been identified, the London Evening Standard reports.
Scotland Yard investigators told the newspaper there are people "of interest" to the inquiry, after they carried out a review of the case.
Detective Chief Superintendent Hamish Campbell, who heads Scotland Yard's Homicide and Serious Crime Command, said a "good number" of individuals should be questioned and urged Portuguese police to investigate the new leads.
Madeleine went missing from an apartment in Praia de Luz, Portugal, in 2007 while her parents Kate and Gerry McCann were in a restaurant nearby.
The Government is in talks with Scotland Yard about introducing water cannons to the force's arsenal.
The Metropolitan Police wants to use two German-made water cannon vehicles, each capable of holding 9,000 litres of water, according to a report in The Times (£).
The Home Office confirmed it is in discussions with the Met, saying, "We will ensure forces have the tools and powers they need to maintain order on our streets".
"We are currently providing advice to ACPO [Association of Chief Police Officers] and the Metropolitan Police as they build the case for the use of water cannon", they added.
After the 2011 riots, the Met stepped up riot training and increased the availability of plastic bullet guns.
The force believes water cannons would be a "valuable" addition when faced with similar situations.
An anniversary appeal for information on the murder of Stephen Lawrence has prompted two "very significant" phone calls, police have said.
The appeal was broadcast on the BBC's Crimewatch programme last night, a week after the 20th anniversary of the racist attack in Eltham, south east London.
Officers are now following up a number of phone calls received after the programme.
Detective Chief Inspector Clive Driscoll said they had many calls last night, but two in particular were "very significant".
"One could produce a potential eyewitness to the attack, and one gives very good background information about suspects already known," he said.
"In addition to that we have also had three phone calls about the green jumper or jacket and we will certainly be making inquiries around those bits of information to verify them."
Read more: Stephen Lawrence appeal launch