Thousands of pupils across England will miss a day of school as their teachers go on strike in a row over pay, pensions and conditions, their unions have announced.
The National Union of Teachers (NUT) and NASUWT say members are fed up with Government reforms which will cut deeper into salaries and force staff to work longer, while pensions pay out less.
Pupils in four regions of England - the North East and Cumbria, the South West, South East and London - will be affected, as members of two of England's biggest teaching unions take part in the second day of walkouts this term.
NASUWT general secretary Chris Keates said the "overwhelming majority" of teachers in these regions would be on strike and blamed education secretary Michael Gove for the industrial action.
"It is the failure and unreasonableness of the Secretary of State, who day-in-day-out is disrupting the education of children and young people through his attacks on the teaching profession."
NASUWT general secretary Chris Keates said the teaching profession is in "crisis" following "three years of attacks by the Coalition Government".
Teachers' unions have announced a rolling programme of regional strikes over the next few months, affecting schools across England and Wales.
It is thought the action could be followed by a national walkout in the autumn over a dispute on pay, pensions, working conditions and jobs.
Education Secretary Michael Gove said in a letter to both unions in March that he was wrote willing to meet them to discuss their dispute, but also insisting that the "direction of travel" on both of their key issues is "fixed".
From this autumn, teachers' pay will be linked to performance in the classroom, with schools setting salaries, rather than following a national framework.
More than 2,500 schools in the North West of England could be affected today as teachers stage a walkout over pay, pensions, working conditions and jobs.
Members of the National Union of Teachers (NUT) and NASUWT will take part in a strike, the first in a planned national rolling programme of strikes across England and Wales which will continue in the Autumn term.
Twenty two authorities, and a possible 2,765 schools, across the North West will be affected as joint rallies are held in Liverpool, Manchester, Chester and Preston.
Chris Keates, General Secretary of the NASUWT, will address the rally in Liverpool at midday.
A Department for Education spokeswoman has insisted that teaching is an attractive profession.
She said the coalition's reforms gave schools "more freedom" with an education system that matched "the world's best". She added:
These are surely ambitions the NUT and NASUWT should be supporting.
We are very disappointed that the NUT and NASUWT have decided to take strike action, which less than a quarter of teachers actually voted for.
Industrial action will disrupt pupils' education, hugely inconvenience parents and damage the profession's reputation in the eyes of the public at a time when our reforms are driving up standards across the country.