NFL commissioner Roger Goodell has said it is a "realistic possibility" that there will be a UK-based franchise if the sport continues to grow in Britain.
For the third successive year, the 2016 season will see three games hosted in the capital, with Twickenham joining Wembley in staging International Series fixtures outside of the United States.
Speaking at a press conference in San Francisco ahead of Sunday's Super Bowl 50, Goodell said he expects more games to be taken to London and did not rule out the possibility of a team one day being based on British soil.
"We are considering playing more games in the UK, it's a balancing act with our schedule," he said.
"As you know, we're playing in two stadiums next year and that gives us a little bit more flexibility of how to do that. I believe the future will see more games in the UK.
"As far as a franchise, let's continue to grow, to see that excitement, enthusiasm, passion and support continue to develop. If it does, I think that's a realistic possibility."
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The NFL and the Rugby Football Union have unveiled a partnership that will see Twickenham host at least three regular-season games over a three-year period.
The deal will start in October 2016, with the teams for the first International Series game at the venue to be announced later this year.
The agreement also gives the NFL the opportunity to stage two extra games over the same period.
The NFL has enjoyed great success in staging matches at Wembley and recently extended its agreement with that stadium, with a minimum of two games per year to be played there through to 2020.
Former Australia rugby league star Jarryd Hayne has realised his dream of winning a place on the San Francisco 49ers' NFL roster.
Hayne beat out practice-squad player Kendall Gaskins for a spot in the running back rotation as the Niners cut 14 players to bring their squad down to the 53-man limit. Another back, Kendall Hunter, was placed on injured reserve.
"I am over the moon," Hayne told 49ers.com. "I'm blessed and honoured to be a part of the 49ers franchise.
"I wanted to take a risk, and I wanted to put myself out there. This whole journey, I've never felt so alive."
Regarding the wait to hear from coach Jim Tomsula, he said: "It was the most nervous I've been in a while. It was more trying to get confirmation than anything. And then it was a sigh of relief."
The first openly gay player drafted by an NFL team is "stepping away" from the game because of fears about his mental health.
Michael Sam, who was selected by the St. Louis Rams in 2014, made the announcement on Twitter, saying the past year had been "very difficult".
The Canadian Football League's Montreal Alouettes, with whom he signed in May, said he had left the team for personal reasons.
The last 12 months have been very difficult for me, to the point where I became concerned with my mental health. Because of this I am 1/3
going to step away from the game at this time. I thank the Alouettes for this opportunity and hope to be back on the field soon. Thank 2/3
you all for your understanding and support. 3/3
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The design of the proposed new stadium is optimised to meet the latest requirements & improvements in stadia design. http://t.co/LJ9me4K4ir
Spurs will host two NFL games a year in their new stadium, the club have confirmed.
The North London club have agreed a ten-year deal with the American Football authorities to have the games played at their replacement for White Hart Lane, which is adjacent to the current site.
NFL games will be played on a completely different surface, something which will protect the turf at the new stadium.
With growing enthusiasm for the NFL in the United Kingdom, we are committed to hosting NFL games in world-class venues and are excited to partner with Tottenham Hotspur to play games at their future stadium.
We share a vision and commitment to creating the best experience for our teams, fans and the local community.
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