NHS England said a report that 500,000 cancer survivors are living with debilitating consequences of the disease draws attention to the "changing nature" of the challenges the NHS has to meet.
A spokesman said, "This is why we have launched a 'call to action' as we need to engage the public and professions in a dialogue about how we create an NHS that meets people's need in a personal way and is fit for the future rather than based on a 20th Century model."
The NHS faces a funding black hole of £30 billion unless there is a "fundamental change" to the way the health care system is run, officials have warned.
A document released by NHS England claims the health service will not survive unless radical changes are made to the delivery of health care, such as hospital closures and the centralisation of services.
If the NHS in England continues to deliver care the way it currently is, there will be a funding gap of £30 billion by 2021 - even if the health budget is protected, the report said.
Health officials also warned pressures on the NHS could lead to another tragedy like the failings seen at Stafford Hospital.
NHS England said it recognises that "a complex range of factors are causing pressures on GP services".
An NHS England spokesman said: "We want to explore with the profession how we can best enable GP practices to continue to provide a quality service and we look forward to working with the RCGP [Royal College of General Practitioners] to identify how best to achieve these goals.
"We are also working with Health Education England and other partners to look at how best to develop the primary care workforce. But it is essential that we also support primary care in making the most effective use of existing resources to improve quality of care".