The participants are debating the future of North Sea oil and whether an independent Scotland's economy would be better off.
Nicola Sturgeon gets the first big clap of the evening, saying: "If Douglas is right and we are overly dependent on oil and we're too poor to be independent, how has this resource-rich country got into that state?
"That's something wrong with how we're being governed. It's not an argument to stay the same, it's an argument for change."
She accuses Westminster of squandering "much of our oil wealth over the last 40 years".
The deputy leaders of the SNP, Nicola Sturgeon, is kicking off the live debate with an opening statement on behalf of the Yes Scotland campaign.
"We are now just days from our chance to make history ... this debate has captured Scotland's imagination," she says.
"Only a Yes vote will guarantee an NHS in public hands and publicly funded, only Yes will rid Scotland of nuclear weapons, only Yes will give us the powers to create jobs and a fair society," she adds.
Deputy First Minister Nicola Sturgeon, Labour MP Jim Murphy and local council leader Gordon Matheson have joined hundreds of people at a memorial service for the 10 people who died in the Clutha helicopter crash.
A spokesman for Scotland's Deputy First Minister Nicola Sturgeon said:
Prime Minister David Cameron has been accused of attempting to "bribe the people of Scotland into voting No" in the referendum with "talk of more powers" while offering "no firm proposals".
Deputy First Minister Nicola Sturgeon said Mr Cameron's address at the Scottish Conservative party conference had "torn up any prospect of a meaningful offer of further powers to Scotland, confirming that a No vote offers no firm proposals".
She added: "In a speech that contained half-hearted, vague suggestions of what might happen, Cameron's reluctance to commit to anything spoke volumes.
"Indeed, the only reason the Tories are even talking about more powers is to attempt to bribe the people of Scotland into voting No - but it is unravelling fast."
David Cameron is "cowardly" for encouraging unity from London and not debating Scottish independence in Edinburgh, the deputy first minister of Scotland has said.
Nicola Sturgeon said the speech was a sign of the "jitters" running through the No vote camp.
Scottish Deputy First Minister Nicola Sturgeon has said that the thoughts of "everybody across Scotland" are with the bereaved.
She said: "It is impossible to imagine the grief and loss they are experiencing but they should know that the thoughts and prayers of everybody across Scotland are with them at this unimaginably difficult time.
"Our thoughts are also with those who remain in hospital. We all hope and pray that those who have suffered injuries make a full and speedy recovery ...
"The police are not just dealing with a very complex incident, they are also dealing with the loss of colleagues, which makes this situation all the more difficult for them."
Scottish Deputy First Minister Nicola Sturgeon has paid tribute to the emergency and health workers, and to the people of Glasgow, who helped deal with last night's incident.
She said: "I think we were all moved last night with the way in which those who were in and around the scene did everything possible to help."
Scottish Deputy First Minister Nicola Sturgeon has described a helicopter crash in Glasgow as "awful news":
Addressing the Scottish parliament, Deputy First Minister Nicola Sturgeon has said that the proposal to extend free childcare will benefit both children and parents by enabling them to return to work.
She received applause for this as well as for her comments on abolishing the so-called bedroom tax and removing Trident nuclear weapons from the country.