The Labour MP whose Bassetlaw constituency includes HMP Ranby said his repeated warnings about "dysfunctional" management and serious staff shortages at the prison had been ignored by ministers and prison officials.
John Mann said: "It is a prison where, for quite a time, it's been clear prisoners have been running the prison."
He added that there were 80 fewer prison officers than previously - a 20% reduction - with many experienced individuals having been "forced out" over the past two years.
He said: "There are not the numbers or the expertise among the staff to deal with it. The governors were warned, the Government was warned, by me and by many others, that this would lead to disaster.
He added: "I have raised this directly with the prisons minister more than once."
HMP Ranby was described as "in crisis" by the Chief Inspector of Prisons Nick Hardwick after a critical report was released about the institution.
Following an unannounced 11-day inspection by HM Inspectorate of Prisons in March, the report found two prisoners died through "self-inflicted deaths" last year, and a further two have died in a similar way since then.
Conditions in part of the prison, which holds more than 1,000 men, were described as dirty and prisoners were found to have climbed netting in a bid to force a transfer to another facility.
Nearly half the population said they had felt unsafe having been victimised or intimidated, findings showed.
Evidence was also found of an increasing number of incidences of self-harm at the category C training prison, and the availability of legal highs was also found to have increased.
Chief Inspector of Prisons Nick Hardwick said the report showed a prison "in crisis".