South Central Ambulance Service spokesman David Gallagher told the Oxford Times: "We’re dealing with two patients, one female and one male, with serious or life-threatening injuries who will be going to the John Radcliffe Hospital Major Trauma Unit.
"We have a further 10 to 15 patients with minor injuries currently being assessed by our staff at the scene.
"The road conditions are reported as being very icy by our staff at the scene."
A Thames Valley Police spokesman said: "Thames Valley Police officers were called today at about 8.25am following reports of a collision involving multiple vehicles on the A40, Witney.
"Officers are at the scene along with the fire and rescue services. A number of people are believed to have been injured.
"Road closures are currently in place, and drivers are advised to avoid the area."
Several people have been injured in four accidents on the A40 in Oxfordshire.
The collisions, involving as many as 20 cars, closed the road between Witney and Burford Road.
An ambulance spokesperson told the Oxford Mail: "We think there at least four collisions. We are trying to work through exactly where people are.
“There are multiple vehicles in multiple accidents and a number of people have been seriously injured."
Sorry, this content isn't available on your device.
The model was one of many celebrities Michael Danaher wanted to target for money, a court heard.Read the full story ›
The site of the collapsed power station could be destroyed as early as this weekend, ITV News understands.Read the full story ›
Thirteen weeks since the power station collapsed and no-one can give the families a clear answer as to when their loved ones will be found.Read the full story ›
The police watchdog is to investigate a police force over its response to a missing teenager whose body was found in the River Thames.Read the full story ›
Around 20,000 tonnes of material is seen in the video as workers continue the recovery operation.Read the full story ›
MD of Coleman and Company, the Didcot demolition firm, has released a statement after former employees said they saw incident coming.Read the full story ›
Fraudsters have been posing as Money Saving Expert founder Martin Lewis to con elderly and vulnerable people out of thousands of pounds.Read the full story ›