The Portuguese inquiry into the disappearance of Madeleine McCann has been reopened amid new leads in the case.
Kate McCann said she wants to defend herself in open court over claims made by the Portuguese police officer who led the hunt for Madeleine.
Prime Minister David Cameron and his wife Samantha have visited a Portuguese fish market at the start of their two-week summer holiday.
Portuguese investigation will run in parallel with Met's Operation Grange #McCann
AC Rowley: "This is a welcome development but both investigations at relatively early stages, with much work remaining to be done" #McCann
The Portuguese attorney general has said new leads mean the formal investigation into Madeleine McCann's disappearance needs to be reopened.
The Home Secretary said she welcomed the news that Portuguese police would re-open the case in to the disappearance of Madeleine McCann.
Theresa May said: "I welcome the developments that have taken place and the work the Metropolitan Police are doing with the Portuguese police on this case. I hope that what we're going to see is a resolution to this case for the sake of Maddie's parents and family."
The parents of Madeleine McCann believe it would be an "important step forward" if Portuguese police reopened the investigation into the disappearance of their daughter.
A spokesman for the couple told the Daily Mirror: “Kate and Gerry don’t want to get their hopes up too much. But if the Portuguese do resume their investigation it would be a significant development and an important step forward.”
Earlier this month, detectives searching for Madeleine McCann ruled out the key sighting that underpinned the original Portuguese investigation and released e-fit images of a different man they wish to speak to who was seen carrying a child on the night she went missing.
Thousands of calls have been made to police in both the UK and across Europe following the recent appeal.
ITV News understands Portuguese police may be about to re-open the investigation into the disappearance of Madeleine McCann.
It is understood a review team, created in March 2012 and involving 37 Portuguese officers, have found two or three new details, which warrant further investigation.
Portuguese police are yet to confirm or deny the reports. Kate and Gerry McCann have always said they would welcome the formal re-opening of the investigation in Portugal.
Kate McCann, the mother of missing Madeleine, has asked for permission to give evidence at the libel trial of the Portuguese detective Goncalo Amoral.
Gerry McCann has already made the same request. The judge is likely to decide on November 5th.
The effects of a book that made allegations about Madeleine McCann's disappearance were worse than when her parents were made arguidos, or formal suspects, Gerry McCann's sister told a court in Portugal.
In her evidence at the libel trial of former police chief Goncalo Amaral, who wrote the book, Trish Cameron said: "This was a different thing. It was much more conclusive and demonising them, dehumanising them, saying they did not care for their children, that they were responsible.
"It makes it out that they weren't truthful and they have been vilified and it's very hard to turn round opinion about them that has been so widely spread."
Mrs Cameron told the court that the Portuguese people had "turned against" the family, adding: "They were fed up with the McCanns, they wanted them to go away, but they weren't going away. They still had a missing child."
Gerry McCann, the father of missing Madeleine, has left a court in Portugal once again without being heard as a witness in the family's libel case against former police inspector Goncalo Amaral.
Mr McCann still does not know whether he will be able to give evidence as no decision has been taken.
Other legal teams are thought to have until October 16 to make submissions on his application, ahead of the judge making her final decision.
Mr McCann said, "Obviously it's disappointing, but we will just keep going."