Rachael Bland, 40, host confirmed the news in a poignant social media post, writing that her "time has come".
The poignant letter from a listener was read out by commentator Jonathan Agnew. Listen with a hanky ready.
Nick Clegg, Boris Johnson, Frank Skinner and Greg James were among the winners at radio's most prestigious awards night.
Michael Christian, one of the Australian radio presenters behind the hoax phone call to the hospital where the Duchess of Cambridge was being treated has returned to the airwaves, according to The Times.
Christian is now presenting a morning show on a Melbourne radio station, however the radio station has yet to officially name him as the presenter of the programme.
A hospital nurse apparently killed herself in December after the hoax phone call which was made by Christian and on air partner Mel Greig.
The pair both resigned from 2Day FM over the death.
A pair of elderly radio stars have picked up one of the industry's most sought-after prizes.