Marin Cilic will play Kyle Edmund in the semi-finals of the Australian Open after Rafael Nadal retired during the deciding set of their clash with a hip problem.
The world number one looked to be on his way to yet another grand slam semi-final when he moved two sets to one in front but he called for the trainer after going a break down in the fourth set.
Nadal took a medical time-out but was clearly hampered in his movement and, after limping around the court for two games at the start of the fifth set, he headed to the net to shake hands.
The 3-6 6-3 6-7 (5/7) 6-2 2-0 victory gave Cilic a first victory over Nadal since 2009 and sent him through to his first Australian Open semi-final since defeat by Andy Murray in 2010.
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World number one Rafael Nadal's ongoing knee injury has seen him pull out of the season-opening Brisbane International.
Nadal was forced to withdraw from the ATP World Tour Finals in November with the issue and he has been unable to sufficiently recover in the off-season.
The Spaniard was due to play in the Mubadala World Tennis Championship in Abu Dhabi this weekend but pulled out earlier this week and he has now cancelled his plans to play in Brisbane.
However, he hopes to be fit for the Australian Open in Melbourne.
He said on Twitter: "I am sorry to announce I won't be coming to Brisbane this year. My intention was to play but I am still not ready after last year's long season and the late start of my preparation.
"I had a great time there and it was a great start to the month I spent in Australia.
"I will be seeing my Aussie fans when I land on the 4th in Melbourne and start there my preparation for the Australian Open."
British number one Andy Murray is due to play in the tournament as he embarks on his comeback from a hip injury.
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Roger Federer delivered a masterclass to beat Rafael Nadal in the final of the Shanghai Masters.
Federer took just one hour and 12 minutes to record a dominant 6-4 6-3 victory against the world number one to secure his sixth title of the year.
The 36-year-old broke Nadal's serve in the opening game of the final and never looked back to claim his fourth victory over his rival in as many matches this season.
World number one Rafael Nadal demolished Nick Kyrgios to win his sixth title of the season at the China Open.
The Spaniard won nine games in a row on his way to a comprehensive 6-2 6-1 victory to reclaim the trophy he last won in 2005.
It was another Jekyll and Hyde performance from the unpredictable Kyrgios, who battled bravely to fend off five break points in his opening service game.
However, having then been angered by a line call the Australian proceeded to complain to the umpire at two changes of end, which eventually cost him a penalty point at the start of the eighth game.
Nadal duly clinched his second break to take the first set, and despite a spirited response from Kyrgios who forced break points in the third game of the second, there was no stopping the 31-year-old.
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