The NFL and the Rugby Football Union have unveiled a partnership that will see Twickenham host at least three regular-season games over a three-year period.
The deal will start in October 2016, with the teams for the first International Series game at the venue to be announced later this year.
The agreement also gives the NFL the opportunity to stage two extra games over the same period.
The NFL has enjoyed great success in staging matches at Wembley and recently extended its agreement with that stadium, with a minimum of two games per year to be played there through to 2020.
England's rugby union governing body has apologised "to those who may have taken offence" to the use of the Victoria Cross on the national side's new playing kit.
England's new Canterbury-manufactured shirts feature Victoria Cross designs that comprise numerous small rubber grips to help deaden the impact of the ball.
Victoria Cross Trust chairman Gary Stapleton criticised the Rugby Football Union (RFU) for having had no contact with the organisation over using the emblem on the kit, which was officially launched earlier this week.
Stapleton said the move "touched a raw nerve with a lot of people."
In a statement, the RFU said:
The Victoria Cross, the British and Commonwealth armed forces' most prestigious medal, has only been awarded 1,354 times during its 158-year existence, most recently in 2012.
The new white England shirt will be worn for the first time when the side begin their autumn Test schedule aganist world champions New Zealand at Twickenham on November 8.
The RFU has confirmed Stuart Lancaster as the new permanent head coach of England.
The Press Association is reporting that the Rugby Football Union has appointed Stuart Lancaster as England head coach.