The UK's highest court is expected to give its decision on right-to-die cases later today.
Nine judges, headed by court President Lord Neuberger, will rule on what has been dubbed a "super-case" - three cases rolled into one which want the law on assisted suicide changed.
One legal battle has been brought by the widow of the late Tony Nicklinson, who has joined forces with severely disabled Paul Lamb, a lorry driver who was paralysed from the neck down in a car accident and a locked-in syndrome sufferer "Martin".
Speaking at the start of the case in December last year, Jane Nicklinson said she was "hopeful" there would be an outcome in her favour and said it was "quite significant" the case would be heard by nine judges, opposed to the usual five.
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Jane Nicklinson, widow of Tony Nicklinson who died last year after enduring many years of locked-in syndrome and fighting for the right to end his own life, said she was feeling hopeful ahead of today's Supreme Court hearing.
Along with Paul Lamb, a paralysed man from Leeds, Mrs Nicklinson want the court to rule that disabled people should have the right to be helped to die with dignity.
Nine Supreme Court justices today began analysisng the issue at a hearing in London due to last four days. Mrs Nicklinson spoke to ITV News outside the court this morning.
Campaigners say a defeat at the Court of Appeal in July has not put them off taking their fight to the Supreme Court today.
Paul Lamb, from Leeds, is immobile except for limited movement in his right hand and has been in significant pain since his accident in 1990.
Along with another accident victim and the widow of campaigner Tony Nicklinson, he will appear at the court in front of nine judges.
Appeal judges dismissed the Nicklinson and Lamb challenges over the legal ban on voluntary euthanasia.
After the July ruling, Mrs Nicklinson said: "We will carry on with the case for as long as we can so that others who find themselves in a position similar to Tony don't have to suffer as he did. Nobody deserves such cruelty.''
Tony Nicklinson's widow has admitted continuing to fight for the right to die the in courts has taken a strain, but added there was "no question" she would continue because she felt "that strongly" about it.
Jane Nicklinson and Paul Lamb, who is severely disabled, want the right to die with the help of a doctor and without the fear of prosecution. Their case will be heard at the highest court in the UK later today.
Jane said she was "hopeful" there would be an outcome in her favour and said it was "quite significant" the case was going to be heard by nine judges, opposed to the usual five.
A right to die case brought by a severely disabled man and the widow of a stroke victim suffering from locked in syndrome will be heard by the highest court in the UK later today.
Jane Nicklinson has continued her late husband's Tony fight for the right to die with help from a doctor, after he passed away after a bout of pneumonia last year.
Paul Lamb joined Jane in the hopes of having a doctor help him end his life without fear of prosecution earlier this year.
The divorced father-of-two was left severely paralysed after a car accident in 1990, has very limited used of his limbs and can only partially move his right hand.
Nine Supreme Court judges will hear the case, opposed to the usual five. Judgement is not expected to be passed until next year.
A memorial rugby match is being played in Kent today as a tribute to right-to-die campaigner Tony Nicklinson, who died in August last year.
His family planned to scatter his ashes at the ground where he used to play ahead of the start of the game, which pits Cranbrook rugby club and the Mad Dogs.
Tony Nicklinson is distraught after losing his High Court battle for a doctor to end his life, legally, at a time of his choosing.
ITV News's Emily Morgan was with the family when they heard the news. He signalled that the news was "devasting". He communicates via his wife and a series of blinks.
The judges ruled that, however understandable the motives may be, any change to the law on assisted dying was a matter for Parliament and not the courts..
Mr Nicklinson describes his life as "pure torture - undignified and intolerable". He was left paralysed below the neck by a stroke.
Professor John Saunders, chairman of the Royal College of Physicians ethics committee, said:
The Royal College of Physicians does not support a change in the law on assisted dying.
It remains illegal for doctors to intentionally and deliberately terminate the life of someone who is not terminally ill.
A survey of RCP fellows and members in 2006 showed that doctors were not in favour of a change in the law to allow them to do this.A change in the law would also have severe implications for the way society views disabled people.