Lawyer Yogi Amin, from Irwin Mitchell, said it was up to Parliament to decide the next steps. He said that, "the law on this sensitive and emotive issue is very clear at present - physician-assisted suicide is unlawful."
This brave attempt at changing the law requires some real public support before the law develops in this respect.
My thoughts are with the family as what they are going through must be a terribly hard situation to deal with.
The pro-lifers argue that 'sanctity of life' as a principle should not be watered down and that to create an exemption in this case may lead to a slippery slope - opening the door to many other classes of cases seeking such an exemption.
This shines a light on the tensions that exist between judge-made law and Parliament, both of which play a key role in our country's unique constitution.
It is clear that there is still plenty to be decided on this law, but the courts have now made it clear that it is for Parliament to decide the next steps.
Pro-life campaigners have welcomed the judges' decision to reject the challenge by two locked-in syndrome sufferers for the legal right to end their life with the help of a doctor.
We welcome the High Court's ruling and we question whether those who have encouraged Mr Nicklinson and 'Martin' to pursue this legal action have the best interests of disabled people at heart.
To legalise killing of those who are suffering would adversely affect many, many people.
We believe that Mr Nicklinson and 'Martin' have lives of equal value to any other member of society.
We urge those around them to rise to the challenge of helping them realise their value and overcome their sense of hopelessness.
We trust that today's judgement will help end the insidious campaign in the British courts to change the law on assisted suicide and euthanasia.
Sarah Wootton, chief executive of Dignity in dying, has said that she was "not surprised" by Tony Nicklinson's case failing in the High Court.
Saimo Chahal, a partner with Mr Nicklinson's solicitors Bindmans LLP, said the next stage of the case would be to prepare an application to appeal against the decision.
She said she would be asking for the case to be expedited so that it can be heard by the Court of Appeal as soon as possible.
Ms Chahal added that Mr Nicklinson's health had deteriorated recently and he was in a great deal of physical pain and discomfort.
She confirmed that he was not prepared to give up his fight to establish the principle of being able to die with dignity when he chooses.
The second man whose right-to-die case was heard by the High Court, referred to as "Martin", 47, has responded to losing his challenge to the legal ban on assisted dying:
I feel even more angry and frustrated now having had this court tell me that I cannot receive professional help to take control of how I might end my own life. My life following my stroke is undignified, distressing and intolerable. I wish to be able to exercise the freedom which everyone else would have - to decide how to end this constant tortuous situation.
Paul Bowen QC, representing Mr Nicklinson, confirmed - as expected - an appeal will be made after the High Court denied his right to have a doctor end his life.
prepared to go all the way with this but unfortunately for me it means yet another period of physical discomfort, misery (contd)
and mental anguish while we find out who controls my life - me or the state".
"It's not the result I was hoping for but it isn't entirely unexpected. Judges, like politicians, are happiest when they can avoid (contd)
confronting the real issues and this judgement is not an exception to the rule. I believe the legal team acting on my behalf is (contd)
Tony Nicklinson, who was left paralysed by a catastrophic stroke, has lost his High Court battle to have a doctor end his life.Read the full story ›
The family of locked-in syndrome sufferer Tony Nicklinson have established an online petition as he waits to learn whether he can be given the right to die.
His daughters are tweeting on his behalf today and appealed for support ahead of the High Court ruling at 2:00pm: