Ellie Simmonds has told ITV News she cannot wait to "chilling, relaxing and catching up on sleep" after her hectic but hugely successful Rio 2016.
The swimmer, who sported her gold and bronze medals in front of the flag-waving crowds at Heathrow Airport, revelled in the return, saying: "It's so nice to just be back home."
The Queen has offered her "warmest congratulations" to Britain's Paralympic athletes for a "magnificent performance" at Rio 2016.
The Rio Games saw ParalympicsGB win 64 golds, the most by a British team since 1988, and a total of 147 medals.
"The magnificent performance of ParalympicsGB this year reflects the talent and commitment of the athletes and their support teams," Her Majesty said.
"I send my good wishes to all those who have contributed to the success of these memorable Games."
Multiple-swimming medallists Ellie Simmonds and Ellie Robinson have led athletes off the second flight carrying ParalympicsGB heroes to land today at Heathrow Airport.
Equestrian golden girl Sophie Christiansen has said repeating her London 2012 medal success in Rio brought her "pure relief".
Clutching her medals, she told ITV News' Amy Lewis how it felt to return to London a winner once again.
Paralympic rowing's first double gold medallist Pam Relph has told ITV News how she couldn't wait for some home comforts after competing in Rio.
A group of 300 ParalympicGB athletes and support staff flew home on the same gold-nosed aircraft - dubbed 'victoRIOus' - that brought Team GB home last month.
As the athletes disembarked a number of medallists, including Sarah Storey, Will Bayley, Lee Pearson and Hannah Cockroft, proudly posed for a photo with their medals.
Dame Sarah Storey has told ITV News how she became "absorbed" in the Paralympic TV experience despite not understanding "a word" of the Brazilian coverage.
The triple gold winner in Rio also hailed the reception she received after returning to Heathrow Airport as GB's most decorated female Paralympian.
The first medal winners from ParalympicsGB have received huge cheers as they made their way through arrivals at Heathrow Airport.
Table tennis gold medal winner Will Bayley - who had an eventful flight home - told ITV News he couldn't wait to see his mum after being back "in the country that I love".
ParalympicsGB table tennis golden boy Will Bayley raised smiles but earned a mild rebuke from air staff after a bit of mischief on the flight back home from Rio 2016.
After proving his ping pong prowess in a challenge, he accepted his celebrating went too far, saying: "When I was on the table I was thinking what am I doing up here?"
ParalympicsGB athletes have been sharing photos of their flight home while enjoying VIP treatment.