Police and medical crews rushed to the scene following a blast at a nightclub in the Romanian capital of Bucharest.
TV footage showed police officers and paramedics trying to resuscitate young people lying on the pavement, while sirens wailed as more ambulances deployed to the scene.
Reuters reported a witness as saying there had been fireworks inside the club and that a pillar and the club ceiling caught fire before the explosion occurred.
Twenty five clubbers are dead in a Bucharest nightclub blast and at least 88 people have been admitted to hospital, government officials said.
"There are 25 deaths so far," Deputy Prime Minister Gabriel Oprea told private television Antena 3 from the scene, where dozens of ambulances and firetrucks rushed to evacuate the injured.
The explosion was reportedly caused by a firework, according to local media.
Deputy Interior Minister Raed Arafat said the death toll may still climb at the club, called Colectiv, which hosted a rock concert attended by up to 400 clubbers.
"There was a stampede of people running out of the club," a man who escaped without shoes told Reuters.
At least 18 people were killed in a blast in a Bucharest nightclub, a government spokesman has confirmed.
Dozens are also believed to be injured in the explosion, which was reportedly caused by a firework.
A witness told local station Realitatea TV one of the fireworks exploded and burned scaffolding that supported the pyrotechnic material.
The scaffolding fell on people who were inside the club and victims claimed the ceiling collapsed.
Victims have reportedly suffered severe burns and others were being resuscitated on the pavement outside of the venue.
Priests trudged through deep snow in a remote Romanian mountain range today to inaugurate a very unusual church.
The chapel is built entirely from ice and snow, and forms part of the Hotel of Ice at Balea Lake in the Fagaras Mountains.
The church, which is covered with decorations and even has an altar carved from ice, will accommodate a busy schedule of weddings, baptisms and concerts.
The Hotel of Ice accommodates guests in 12 double rooms, where the temperature hovers between -2 and 2 degrees Celsius.
The Chancellor George Osborne has insisted the government will continue to fight for Britain and British interests in Europe.
His comments come after reports from Germany that Chancellor Angela Merkel has threatened to withdraw her support for keeping Britain in the EU if David Cameron continued in his drive to curb immigration from other EU countries, in defiance of the EU policy on the free movement of people.
Former Chelsea striker Adrian Mutu has failed to obtain a Indian visa after being turned away by their embassy in Bucharest for being drunk, according to reports in Gazzetta dello Sport.
Mutu, 35, has signed a three-month deal to play for FC Pune City in the newly-formed Indian Super League, but his arrival in the country has now been delayed.
The ex-Romania international reportedly arrived 'visibly drunk' at the embassy and threatened staff when proceedings dragged on.
Due to his inebriation and behaviour Mutu was asked to return sober at a later date to get his visa.
Mutu is no stranger to controversy having been sacked by Chelsea in 2004 after testing positive for cocaine.
A staff member of the British embassy in Romania died today after reportedly falling from a hotel roof.
The 46-year-old man, who has not been identified, fell from the Hotel Mara in Baia Mare, in Maramures, north west Romania, according to the BNO news agency.
Sir Simon Fraser, the Permanent Under Secretary of the Foreign and Commonwealth Office (FC) said: "I am deeply saddened to confirm the tragic death of a member of our diplomatic staff in Romania."
"We ask for the privacy of the family and our Embassy team in Bucharest be respected at this difficult time."
Around two dozen Romanians have entered the UK since border controls were lifted, according to the country's ambassador in London.
Speaking to The Telegraph, Ion Jinga claims that the predicted rush of Romanians into the UK has not happened, and that only a handful of Romanians have arrived in Britain in the two weeks since immigration restrictions were relaxed.
Border officials here have not published figures showing how many Romanians have entered the country.
But Dr Jinga told the Telegraph that 21 Romanians have arrived in Holland, where registration is required, and he claims this figure will be similar for the UK.
As flights and buses arriving today showed, many Romanians and Bulgarians have been living in Britain for years.
But we should also be welcoming new arrivals, just as Britons arriving in France, Spain and other European states find themselves welcomed.
It's time to end the toxic immigration debate and acknowledge that, whether they are nurses and doctors coming to work in the NHS, computer game designers or building workers, Romanians and Bulgarians, as with other immigrants, will be contributing to our society.
Some will settle, some will only be here for a few years, and they reflect the mobile nature of life in the modern world which enriches all of our lives.
Victor Spiresau has arrived in the UK from Romania today in order to find a job in construction, he told ITV News.
The 30-year-old said he earned 10 euros a day working on building sites at home and that he hopes to make 10 euros an hour here, but was not planning on settling.
"I don't want to stay here. I want to renovate my home and to make a good life in Romania because it's much easier to live in Romania because it's not expensive."
Mr Spiresau said he already has work lined up washing cars in London but hopes to go on to work in the construction industry. He said he chose to come to the UK over other European countries as he can speak the language.