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Owen Farrell has been ruled out of England's entire RBS 6 Nations campaign with a knee injury.
The Saracens fly-half, who was expected to supply midfield cover from the bench, suffered a high grade medial ligament strain in Sunday's European Champions Cup defeat at Clermont
"It's a real shame for Owen that he sustained this injury and we wish him the best for his recovery," head coach Stuart Lancaster said.
BREAKING NEWS: Fly half Owen Farrell has been ruled out of the 2015 RBS 6 Nations with a high-grade medial ligament strain #getwellsoon
Farrell's absence has opened the door for Danny Cipriani to claim a place on the bench against Wales on Friday week with George Ford starting the Championship opener at the Millennium Stadium.
Cipriani is competing with Stephen Myler to supply cover for Ford and will have a week's training at the squad's Pennyhill Park training base to argue his case for selection.
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An all-Ireland bid to stage the 2023 Rugby World Cup will be unveiled today.
Political leaders from the Northern Ireland Executive and Irish government will join senior officials from the Irish Rugby Football Union (IRFU) to outline their ambition to jointly host the sport's showpiece event.
Both administrations have been engaged in a preliminary assessment exercise over the last 10 months to weigh up the feasibility of submitting an official bid.
The all-Ireland bid is expected to be given the go-ahead at an event in Armagh this morning.
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Chris Henry suffered 'a temporary blockage of a small blood vessel in his brain' on the morning of Ireland's clash with the Springboks, team bosses have confirmed.
Ireland medics initially diagnosed a virus on the morning of the November 8 clash before suspecting a severe migraine, but specialists have since determined the Ulster flanker suffered a more unusual condition.
The 30-year-old missed Ireland's 29-15 Springboks victory and now 'needs further investigation and specialist opinion,' according to an Irish Rugby Football Union (IRFU) statement.
Chris Henry suffered some weakness on the morning of the South Africa game and a viral illness was suspected, he recovered quickly and the initial diagnosis was of severe migraine.
Further tests however have shown he suffered a temporary blockage of a small blood vessel in his brain.
He is at home now and is well but needs further investigation and specialist opinion.
England winger Anthony Watson has admitted that his own mother hates watching him play, preferring snooker and tennis.
England head coach Stuart Lancaster has given his backing to winger Anthony Watson ahead of his first international start.
Watson, 20, made his debut in the defeat to Australia on Saturday, but gets a place in the side from kick-off against South Africa this weekend.
"Anthony has been pushing hard for a while," said Lancaster. "He has got all the physical attributes you need. He's tall, good in the air, has pace and good footwork. Now his experience will be tested.
"His chance has come because of the injury to Roko, and his form for Bath this season, but also because of the conversation I had with him before the New Zealand match.
"It would have a big step for a 20-year-old to go into a match against the world champions from the start but what came across was how confident he was and how prepared he was. He is definitely ready."