David Cameron discussed the portion of his speech which alluded to his son Ivan with his wife before using him as an example in the Prime Minister's attack on Labour.
The Prime Minister said his family know more than most how important the NHS is after going to hospital "night after night" with their disabled son, who was born with a rare genetic condition and died in 2009, aged six.
Aides said Mr Cameron had discussed with his wife whether to include the passage in his speech and that Samantha was "very strongly and personally passionate" about the need to discuss the NHS and its effect on their lives.
David Cameron is reportedly jetting off to the Canary Islands for Parliament's Easter break.
The Prime Minister is expected fly to Lanzarote this weekend with his wife Samantha and their three children.
It will not be the first time the Camerons have holidayed on a Spanish island - they have previously taken trips to Ibiza and Mallorca.
The Prime Minister, his wife Samantha Cameron and their children have run the Sport Relief Mile.
David Cameron and his family completed the Sainsbury's sponsored charity event at Cutteslowe Park in Oxford.
Mr Cameron said afterwards: "Sport Relief brings together some of the best things about Britain - we are a great sporting nation but also one of the most generous countries when it comes to contributing to good causes.
"This is the third time I have run the Sport Relief mile and I am delighted to have taken part in such a fantastic event that is bringing people across the UK together to get active, raise money and change lives."
Whenthe new immigration minister James Brokenshire attacked what he called the "wealthy, metropolitan elite" for benefiting from cheap foreign labour, it's unlikely he meant to point the finger at the Prime Minister.
But his words have now come back to haunt the government, after it emerged the Camerons had hired a Nepalese woman as a nanny who later gained British citizenship.
She had put Samantha Cameron down as her employer but there was no special pleading on her behalf.
Do these domestic arrangements really matter politically? Well, it shows what a sensitive subject immigration continues to be - and why getting the tone right can be tricky.
Downing Street has insisted David Cameron followed all the "proper processes" after it emerged his family's Nepalese nanny has been granted British citizenship.
Questions were raised about Mr Cameron's use of foreign domestic help after a minister deplored the effects of the "metropolitan elite" using cheap migrant workers.
Home Office minister James Brokenshire said yesterday the wealthy had been the main winners from Britain's openness to labour from abroad, because they had to pay less for tradesmen and services.
The Prime Minister and First Lady have arrived at the Conservative Party conference in Manchester ahead of his keynote speech.
David Cameron and his wife Samantha have been photographed on a sunny break in Polzeath.
The Prime Minister, who has received a painkilling injection after [complaining about a "phenomenally bad back", was pictured visiting the small beach village in north Cornwall.
The couple were dressed in complementary blue tones, with Mr Cameron opting for a navy polo shirt and matching shorts, while his wife wore a denim blouse teamed with beige chino shorts.
Mr Cameron appeared relaxed, with his top button undone, showing little signs of the pain he has been suffering.
It is not the first time the Camerons have visited Polzeath. Last year they braved blustery showers to have lunch at a beach-front cafe where they shared a bowl of local mussels on the terrace during a gap in the rain.
The couple have visited Cornwall for the last few summers and it was where their younger daughter Florence was born in 2010.
Downing Street has played down reports that David Cameron was being pushed into taking more action on Syria by his wife Samantha Cameron.
The Times quoted a Cabinet Minister saying that Mrs Cameron was the "biggest explanation" for the Prime Minister's stance on the conflict.
Whilst acknowledging that Samantha Cameron had been affected by her visit to Syria, the Prime Minster's spokesman insisted that policy on Syria was a matter for the National Security Council:
"I would proceed with a fair bit of caution on this one. The Government's approach to Syria is driven through the National Security Council. That is where our policy and approach is driven."
Samantha Cameron visited Syrian refugees in Lebanon in March and is cited as the "biggest explanation" for the Prime Minister's stance over the conflict.
Sources close to Mr Cameron confirmed to the paper that his wife had pushed for a more robust response to the humanitarian crisis.