Steven Gerrard has been ruled out for two to three weeks with a hamstring problem which will keep him sidelined for this weekend's FA Cup trip to Crystal Palace, and the league fixtures against Southampton and Man City.
With Lucas Leiva already out for at least a month with a thigh problem it means Jordan Henderson and Joe Allen are likely to be paired in central midfield.
Forward Raheem Sterling, who missed the midweek league win over Tottenham with a foot injury, has to be assessed while youngster Jordon Ibe is cup-tied.
Liverpool squad: Mignolet, Can, Skrtel, Sakho, Markovic, Allen, Henderson, Moreno, Coutinho, Lallana, Sturridge, Jones, Ward, Johnson, Manquillo, Enrique, Borini, Lambert, Balotelli.
Outgoing Liverpool captain Steven Gerrard will wear the number eight at LA Galaxy when he completes his move to America at the end of this Premier League season.
If you want to buy the shirt is will cost you $174.99 - which is a whopping £114.15.
What an achievement from the former England skipper. Will he guide Liverpool to one last trophy before moving to America?
Rested captain Steven Gerrard watched on from the stands as Raheem Sterling gave Liverpool a second half lead against West Ham.
Jose Mourinho has urged Chelsea fans to stop giving Steven Gerrard a hard time over his costly slip at Anfield last season.
Liverpool's captain fell over with the ball at his feet when Chelsea visited Anfield in a crucial Premier League clash in April 2014.
The Blues broke away and took the lead, eventually winning the fixture 2-0 and effectively ending Liverpool and Gerrard's hopes of collecting his first ever league title.
Chelsea fans will travel to Liverpool in their thousands for Tuesday's meeting, but Mourinho wants them to scrap any chants directed at Gerrard.
Gerrard is an historical player for Liverpool, an historical player for the Premier League, an opponent I always admired and respect. Our fans have a song (about him) that I don’t like, I don’t like it at all.
Maybe a couple of times it’s good fun, but to go on and go on, especially when a player like him deserves respect, I don’t think we need that. We have so many other songs that we don’t need that one.
I love those quotes when Gerrard was saying that, in this life, he would never score against Liverpool. I understand why he was almost, almost, almost coming to Chelsea, and he didn’t. I respect that a lot.
The decision (to stay at Liverpool) for me was proven right because he will always be a Red for ever.
Chelsea manager Jose Mourinho admits failing to sign Liverpool captain Steven Gerrard is one of the biggest disappointments in his careerRead the full story ›
Los Angeles Galaxy coach Bruce Arena has confirmed Liverpool captain Steven Gerrard will join the club in JulyRead the full story ›
Liverpool captain Steven Gerrard's move to LA Galaxy could be confirmed today.
Press Association Sport understands a deal to take the 34-year-old to the Major League Soccer at the end of this season is now close to completion.
However, contrary to reports Gerrard has not been given leave to travel to the United States to finalise the move and has not flown to America as all the necessary requirements associated with the deal have been done in this country.
Departing Liverpool captain Steven Gerrard insists he is not pointing the finger but the revelation he would have signed a new contract last summer leaves the Reds' hierarchy with questions to answer.
The midfielder, who turns 35 in May, will leave the club he has been associated with since he was eight at the end of the season after turning down a new deal.
That offer was made in November but had it come three months earlier the Reds would still be looking forward to another season with their inspirational captain.
If a contract had been put in front of me in pre-season I would have signed it. I'd just retired from England to concentrate all my efforts on Liverpool. I didn't want my club games to be tailored.
My injury record had been fantastic for the past two and a half years and I had a great season from a personal point of view last season.
It's all ifs, buts and hindsight now. That period between the summer and the end of November gave me thinking time.