Pressure had been building on ambassador Susan Rice after she admitted releasing incorrect information following the September 11 attack on the American consulate in Libya.
The attack left four Americans dead, including the Ambassador to Libya, Christopher Stevens.
Rice initially said the attack had followed protests over an anti-Islamic film, but later intelligence reports suggested a possible al-Qaeda connection.
Rice, the US Ambassador to the UN, admitted her mistake in late November, but several Republican senators said questions remained unanswered.
After Rice pulled out of the running to become Secretary of State today, Republicans vowed to continue "seeking the facts" about Benghazi.
Two Republican senators who were heavily critical and opposed Rice’s potential nomination as US Secretary of State have commented on her decision to quit the race:
As Susan Rice withdraws her name, the way is now open for Senator John Kerry to "report for duty" as America's next Secretary of State.
The CBS White House correspondent Mark Knoller has reaction from President Obama to Susan Rice's withdrawal from the race to be the next US Secretary of State:
The US ambassador to the UN Susan Rice has told NBC News she is withdrawing from the race to succeed Hillary Clinton as US Secretary of State.
The US ambassador to the UN, Susan Rice, has tweeted her expectations that the United Nations must act on its condemnation of North Korea for its rocket launch: