Clinical trial testing for a malaria vaccine in a small group of people could begin within 18 months, researchers said.
Doctor Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases said researchers found "a novel and different type of an approach toward a vaccine".
He added: "It's profoundly important to develop an effective malaria vaccine."
Director of Rhode Island Hospital's Center for International Health Research, doctor Jonathan Kurtis, said researchers found that antibodies sent by the body's immune system, acted on a protein and trapped the parasites inside the red blood cells, blocking the progression of the disease.
A promising new approach intended to imprison malaria causing parasites inside infected red blood cells has been developed by scientists.
Researchers said an experimental vaccine based on this idea protected mice in five trials and will be tested on lab monkeys beginning in the next four to six weeks. The disease kills a child every minute in Africa.
Using blood samples and epidemiological data collected from hundreds of children in Tanzania, where malaria is endemic, the researchers pinpointed a protein, called PfSEA-1, that the parasites need in order to escape from inside red blood cells they infect as they cause malaria.
Gunmen forced a group of 16 British school pupils and staff from their vehicle during a roadside ambush on an expedition in Africa.
Money, cameras and mobile phones were stolen as the robbers rifled through their belongings during the hold-up in the Tabora region of Tanzania.
The 14 students, aged 15 to 18, and two staff members from the private Cranbrook School in Kent were "shaken" but uninjured following the robbery last month.
Headmaster John Weeds said, "We understand that the police have got to the bottom of who was responsible," as local reports suggest four men are due in court after admitting robbery.
Tanzania has arrested a British man suspected of involvement in unspecified "terrorism activities" in the UK, according to local police.
Iqbal Ahsan Ali was arrested in Tanzania's southern Mbeya region after being found in possession of both British and Tanzanian passports, a crime in Tanzania which forbids dual citizenship.
"We have been in contact with our counterparts in the UK and they have confirmed that the suspect is wanted in their country for involvement in terrorism activities," Robert Manumba, director of criminal investigations
Manumba did not give further details of what Ali was sought for in Britain. British diplomats in Tanzania made no immediate comment.
Police said they had verified Ali's British passport as being authentic but said the Tanzanian passport he was carrying was fake.
US President Barack Obama and his family will travel to Tanzania today on the last stop of their African trip.
Mr Obama will visit the Presidential State House for an official greeting by President Jakaya Kikwete before the two leaders hold a joint press conference.
The rest of the day will involve meetings with business leaders and an Official Dinner in the State House .
A ferry with more than 280 people on board, including some foreigners, has capsized and sank off the coast of Zanzibar in Tanzania, killing at least 24 people.
The Tanzanian government have said that so far 145 people have been rescued and so far "twenty-four bodies have been recovered."
Rescue boats and divers are searching for any remaining survivors.
One foreigner, a woman, is said to be among the dead and thirteen other foreigners have been rescued and are being treated in hospital, according to the Tanzanian government.
Police said the vessel was carrying 250 adults and 31 children when it capsized near Chumbe island, west of Zanzibar.