Locked-in syndrome sufferer Tony Nicklinson's widow and a paralysed victim have pledged to continue to challenge right-to-die law.
Disability charity Scope explains why it believes disabled people should not have the right to take their own lives.
Locked-in syndrome sufferer Tony Nicklinson campaigned for years to win the right to end his life. Here is the timeline of his struggle.
Paul Lamb has told ITV News he is "pleased" that he and the Nicklinson family can take their right-to-die challenges to the Supreme Court and is "already planning to be there".
The Nicklinsons earlier confirmed the Court of Appeal had cleared them to appeal to the higher court and Mr Lamb said, as far as he is concerned, he has been granted leave to appeal too.
Paul Lamb has told ITV News he will "never give up" his legal battle for the right to die.
He says he "had little hope" of a ruling in his favour, but is ready to appeal again to the Supreme Court.
"The judge said he had 'sympathy' for me," Mr Lamb said. "I hate that word. Sympathy is no good to me. When he talked about sympathy I just wanted to shout at him.
"If they had a dog that was in the same pain as I am, they wouldn't allow it. The law is just cruel," he added. "There are thousands of people like me, and all we want is the individual right to choose how to end our lives."
The Court of Appeal has granted us permission to appeal to the Supreme Court #righttodie
Right-to-die campaigner Paul Lamb has said he is "absolutely gutted" by the Court of Appeal ruling against his challenge.
"I was hoping for a humane and dignified end," he said. "This judgment does not give me that."
Like the family of Tony Nicklinson, Mr Lamb pledged to continue to challenge the law despite the latest defeat.
"I will carry on the legal fight - this is not just about me but about many, many other people who are being denied the right to die a humane and dignified death just because the law is too scared to grapple with these issues," he said.
To which Tony Nicklinson's family responded:
Gutted we lost our appeal but we will appeal this decision and keep on fighting. The courts cannot continue to ignore the issue #righttodie
Tony Nicklinson's family, have confirmed they will appeal the Court of Appeal's ruling against them, have also praised the judges' ruling in favour of one of the three right-to-die challenges.
Pleased to hear that Martin won his appeal, at least that is something and a small step in the right direction #righttodie
Right-to-die campaigner Paul Lamb, who wants a doctor to help him die in a dignified way, was not present for the reading of the unsuccessful ruling at the Court of Appeal.
The ruling was made by the Lord Chief Justice Lord Judge, Master of the Rolls Lord Dyson and Lord Justice Elias in London.
The trio had heard argument that people who are too sick or disabled to end their "unbearable" lives without help are currently being condemned to "suffer in silence or make desperate attempts to kill themselves".
Mr Lamb, 57, from Leeds, had won the right to join the litigation to continue the battle started by Mr Nicklinson, who died at home last August, a week after he lost a High Court bid to end his life with a doctor's help.
We are sorry to say that we have lost our Court of Appeal challenge. We will continue the legal campaign & appeal again #righttodie
The family of late locked-in syndrome sufferer Tony Nicklinson and paralysed road accident victim Paul Lamb have lost their right-to-die challenges at the Court of Appeal in London.
Three judges rejected the Nicklinson and Lamb cases, but in a majority ruling the court allowed an appeal by a locked-in syndrome sufferer known as "Martin".
He had sought clarification of Director of Public Prosecution guidance relating to the position of health professionals in assisted suicide cases.