Tottenham left Mousa Dembele, Danny Rose and Kyle Walker at home as they embarked on the 11-hour round trip to Azerbaijan to face Qarabag in the Europa League.
Boss Mauricio Pochettino rested the trio with Sunday's Barclays Premier League clash with Chelsea in mind, while he is also without Erik Lamela (groin), Nabil Bentaleb, Nacer Chadli and Alex Pritchard (all ankle) through injury.
But in-form striker Harry Kane travelled to Baku along with England new boy Dele Alli, who is set to start as he is suspended at the weekend. Spurs will seal their qualification into the knock-out stages with a victory.
Spurs squad: Lloris, Vorm, McGee, Trippier, Alderweireld, Wimmer, Vertonghen, Fazio, Davies, Carter-Vickers, Winks, Dier, Mason, Carroll, Alli, Townsend, Eriksen, Onomah, Son Heung-min, Njie, Kane, Harrison.
Chelsea captain John Terry is expected to miss Sunday's Premier League clash at Tottenham, with Jose Mourinho blaming a "dangerous" pitch for his ankle problem.
The 34-year-old Blues skipper was taken off on a stretcher during Chelsea's 4-0 Champions League Group G win at Maccabi Tel Aviv on Tuesday night and is likely to face scans to determine the extent of the problem.
"For John to leave the pitch with the result 1-0 I know already that he is in trouble," Mourinho said.
"My medical department is really good. John is a special guy, with a special desire to recover.
"(But) to leave the pitch with the result 1-0, I don't believe too much that he can play (against Spurs)."
Chelsea could also be without Ramires, who was absent from the matchday squad after suffering an injury in training on Monday, when Chelsea tried to preserve the pitch.
"The surface was bad and dangerous," Mourinho added. The pitch was really bad. Ramires slid and had a muscular injury."
A 35-year-old man who was stabbed outside White Hart Lane on Sunday has been discharged from hospital, according to West Ham's website.
The incident happened at approximately 3pm ahead of Tottenham's Premier League match with West Ham around the junction of White Hart Lane and Tottenham High Road.
The victim suffered a stab wound to the abdomen and was taken to an east London hospital but no arrests have yet been made following the Metropolitan Police's initial appeal for information and witnesses.
A West Ham club statement read:
West Ham United can confirm that the gentleman who suffered a stab wound in White Hart Lane on Sunday has been discharged from hospital following treatment.
The club would like to wish the supporter concerned a continued speedy recovery.
Anyone with any information is asked to contact Haringey CID on 0203 276 3070 or Crimestoppers anonymously on 0800 555 111.
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Spurs playmaker Christian Eriksen couldn't resist some keepie-uppie action as he relaxed at home after Sunday's win over West Ham.
The Danish international impressed once again as Tottenham stretched their unbeaten Premier League run to 12 matches with a convincing 4-1 victory.
Clearly unimpressed with what Crystal Palace and Sunderland dished up on Monday Night Football, he treated followers to some textbook close-control with a small-size football.
Eriksen and his Spurs team-mates travel to Azerbaijan for a Europa League match against Qarabag on Thursday before Sunday's Premier League meeting with Chelsea at White Hart Lane.
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Mauricio Pochettino insists it is too early to talk about Tottenham as title contenders but believes his side do have enough quality to make the top four.
Two goals from Harry Kane and one each from Toby Alderweireld and Kyle Walker helped Spurs thrash West Ham 4-1 on Sunday, a win that equals the club's record of 12 league matches unbeaten. Manuel Lanzini scored a late consolation for the Hammers.
The victory puts Tottenham four points behind surprise table-toppers Leicester, and with Arsenal, Manchester City and Manchester United all unconvincing in recent weeks, Pochettino's side seem capable of keeping pace at the top.
It is early to start talking about that, there is too far until the end of the season.
We have a young squad, we need to develop our way to be consistent. It is true we have shown from the beginning of the season we are consistent but to win the title we need more.
It is step by step. It is difficult to say today what will happen in four or five months. We need to keep working hard and stay with our feet on the ground.
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