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Jan Vertonghen is out until December with a hamstring injury, Tottenham have announced.
The defender was injured in the Premier League win at Huddersfield earlier this month.
Spurs said: "The Belgium international defender will now continue his recovery with a view to returning to full training by December."
Belgium boss Roberto Martinez last week said Vertonghen would miss the international breaks this month and in November due to the problem.
Spurs boss Mauricio Pochettino revealed the defender would undergo a further scan, the results of which show the extent of the problem.
Vertoghen sustained the injury in a collision with Huddersfield striker Laurent Depoitre early in the game, but continued until half-time, thinking it was a dead leg.
Cardiff have lost their appeal against Joe Ralls' red card at Tottenham.
Ralls was sent off by referee Mike Dean for a 58th-minute tackle on Lucas Moura in Saturday's 1-0 Premier League defeat at Wembley.
The Bluebirds challenged the red card, but their appeal has been rejected by the Football Association.
After the game, Cardiff manager Neil Warnock branded the decision as "very soft" and accused Spurs striker Harry Kane of "trying to make an issue of it" by squaring up to Ralls.
"You don't go off like that. He (Kane) is doing that to make an issue of it, to get the referee thinking (it was) worse than what it is," Warnock said.
"I don't think you should try to get other pros sent off, just because he's had a poor game and Spurs were having a poor game. He shouldn't take it out on us."
Ralls will now serve a three-game ban and miss matches against Fulham, Liverpool and Leicester.
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Christian Eriksen, Mousa Dembele and Jan Vertonghen were absent from Tottenham training ahead of tomorrow night's clash with Barcelona at Wembley.
Vertonghen and Dembele came off at half-time at Huddersfield on Saturday while Eriksen has been carrying a groin problem.
Manager Mauricio Pochettino will give an update on the trio when he faces the media at 1pm.
Goalkeeper Hugo Lloris was back in training after a thigh injury but Dele Alli, as expected, was missing with his hamstring problem.
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