Unicef UK ambassador Ewan McGregor has warned "famine is looming" in South Sudan in the charity's latest appeal to help at-risk children.
A video featuring a host of film stars and musicians has been released to highlight the plight of children caught up in the Syria conflict.
Singer Katy Perry took a trip to Madagascar in support of UNICEF to help draw attention to the plight of many on the island.
The story of three-month-old Wala'a, who has been left malnourished after her family struggled to find food in a besieged area of Damascus in not an isolated case according to UNICEF.
Maria Calivis, UNICEF Regional Director for the Middle East and North Africa told ITV News:
"It's a tragedy and any one child reduced to this condition, its both a tradegy and a failure of our system.
"Any case like that of little Wala'a is no doubt a tradedy, a tragedy for the family and a tragedy that can repeat itself over and over again, if the crisis does not end."
Speaking of the siege in Homs, she added: "The first tragedy that all families speak about is about the loss, the insecurity of food, the access to food and to survive they often had to go to their neighbour, their neighbours and neighbours that had fled in order to search for food.
"And sometimes even when that was not enough, they resorted to plants, to feeding themselves in whatever way they possible."
David Beckham has visited the Philippines as part of Unicef's relief efforts in the devastated country.
The former England captain was welcomed by hundreds of Typhoon victims in the central city of Tacloban who have been living in United Nations tents outside a sports stadium.
The 38-year-old exchanged high-fives and posed for pictures with children.
Tacloban is still struggling to recover from the impact of Typhoon Haiyan which struck last November killing 6,200 people and displacing thousands more.
Zafrin Chowdhury, a spokeswoman for the Unicef office in Manila, said Beckham was touched by the typhoon's impact and wanted to meet displaced children and their families.
Beckham and his wife Victoria have previously donated some of their designer clothes and shoes to raise funds for the victims of the disaster.
International Development Secretary Justine Greening has told ITV News the government will match donations made to UNICEF's Syrian appeal for a three month period.
The charity are raising aid to assist children caught up in the crisis and they estimate that four million youngsters are in urgent need of help.
Ms Greening told ITV News: "UNICEF has played a leading role in trying to provide support to the millions of children who've been affected by this crisis.
"We haven't just seen lives lost during the Syrian crisis so far, we've seen childhoods lost as well.
"So, we want to back the British people's generosity pound-for-pound in their support for this UNICEF appeal and it will not just go towards helping children stay healthy and stay safe today, it will also go into education so it will help build their futures tomorrow."
The singer Emma Bunton is spearheading a new campaign to make sure families are protected against a deadly strain of tetanus.
It is estimated that at least 100 million mothers and children living in the world's poorest countries are vulnerable to Maternal and Neonatal Tetanus, or MNT.
Emma Bunton explained more to ITV News presenter James Mates:
As the UN has called for immediate access to Syria to address the humanitarian issue, Unicef has said that full unconditional humanitarian access in Syria is needed as there are children trapped in conflict zones, desperate for aid, who they are unable to reach.
- Availability of water has decreased by a third inside Syria compared to pre-crisis levels
- Up to 60% of public hospitals have limited or no capacity and around 80% of the nation’s ambulances have been destroyed
- More than 4 million Syrian children are now in urgent need of humanitarian aid, including more than 1 million children who have fled Syria as refugees
- Treatment of sewage has declined dramatically
The number of refugees fleeing Syria for camps in Iraq and Jordan is "astonishing", children's charity UNICEF has said to Daybreak.
Jon Sparkes, who recently returned from the Iraq camp, described problems with fresh water, sanitation and the legacy of "a generation" of displaced children.
Martin Dawes, Regional Spokesperson UNICEF West and central Africa said: "There is still time to avert a catastrophe amongst children inthe Sahel region of West Africa.
"1.1 million children over the course of this year will need life saving intervention because of severe acute malnutrition. This is a crisis with multiple causes where adults will suffer but children will die.
"5,200 nutrition treatment centres have been set up in nine countries but the next two month will be extremely hard for children and their mothers. Most at risk are those who become malnourished and fall prey to conditions such as malaria and diarrhoea."