Republic of Ireland captain Seamus Coleman is due to undergo surgery on Saturday as he faces a lengthy spell on the sidelines.
Press Association Sport understands the 28-year-old Everton full-back suffered a double fracture of his lower right leg during Friday night's 0-0 World Cup qualifier draw with Wales at the Aviva Stadium in Dublin.
Coleman was hurt in a challenge by Wales wing-back Neil Taylor, who was sent off as a result, 69 minutes into a stormy affair.
He was treated at length on the pitch and was given oxygen as he was comforted by team-mate Shane Long, and eventually left on a stretcher.
Coleman was taken straight to St Vincent's University Hospital in the city, where he was due to have screws inserted to help repair the damage on Saturday.
Chris Coleman defended Neil Taylor after Republic of Ireland defender Seamus Coleman was left with a broken leg in their fierce World Cup qualifier in Dublin.
The Everton full-back was carried from the field on a stretcher after Taylor had been shown a straight red card for his 69th-minute tackle during Friday night's goalless draw.
The Football Association of Ireland confirmed later that Coleman had broken his right leg and the Republic captain is expected to undergo surgery on Saturday.
Television underlined the severity of the injury by choosing not to show replays of the incident which ended Coleman's season.
"Sadly for Seamus, obviously, it looks like it's a bad one," Wales manager Coleman said, adding Taylor had gone into the Republic dressing room at the end of the match to see the Ireland captain.
"Neil Taylor is not that type of player. He's had a serious injury himself. He's a great boy, he's a cracking lad. I've not seen the challenge, but I've seen the outcome, if you like, and it's a bad one for Seamus.
"Yes, it looks like he (Taylor) has got that one wrong on our part. I've only seen it in real time when it happened and I didn't see a lot. I saw the reaction. I have seen a picture of the outcome, so my thoughts are with Seamus.
"Of course, Neil is devastated himself. But, no, I never said to Neil, 'What were you thinking?'"
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Wales boss Chris Coleman has told Republic of Ireland to forget about trying to goad Gareth Bale in their World Cup qualifier.
Real Madrid forward Bale returns from a two-match La Liga ban at Athletic Bilbao on Saturday after being sent off against Las Palmas.
Bale picked up the second red card of his career for shoving Las Palmas midfielder Jonathan Viera to the ground during an ill-tempered 3-3 draw.
But Coleman is confident Bale will keep his head in the white-hot atmosphere of Dublin's Aviva Stadium next week.
Anybody sensible looking at him will see he never does that. I don't even know what happened. But he is a human being and sometimes you do something and regret it.
If you look at his past, though, and he has been kicked from pillar to post, I won't be worried.
I remember when we played Scotland and some ex-Scottish player said, 'He can't play if he hasn't got any legs.'
I looked at that and thought, 'Does he really seriously think that is going to bother him?' If you look and see where he is playing, under the pressure, in the spotlight, week in, week out...
So whatever the opposition have got planned for him, he's seen it before and dealt with it before. I'm not at all worried.
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Liverpool teenager Ben Woodburn could join Wales' World Cup campaign against the Republic of Ireland next week - and end doubts over his international future.
Woodburn became the youngest scorer in Liverpool history - at the age of 17 years and 45 days - when he netted in the 2-0 EFL Cup victory over Leeds in November.
His Liverpool debut came as a substitute against Sunderland in November, and he has now made seven appearances.
Woodburn's Liverpool team-mate Harry Wilson—who became Wales' youngest player at the age of 16 years and 207 days when he played against Belgium in October 2013—is also under consideration for a call-up after impressing at Anfield in recent months.
Wilson, now 19, made his Liverpool debut in the FA Cup victory at Plymouth in January and was also on the bench for the weekend win against Burnley.
It is Woodburn who has made the big recent impact though, and while he has yet to start a Premier League game he produced an impressive cameo off the bench in the Reds' 2-1 triumph against Burnley on Sunday and Wales assistant manager Osian Roberts told S4C that he is close to a senior call-up.
He's knocking on the door now. What's definite is that there are a lot of young players in this group doing that. And we need that. We're really pleased with them.
A lot of them have already been in our camps for a week at a time to get that experience, so they can make that step when the chance comes.
It's important we have that freshness as we move on.
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Scotland ended 10 years of hurt against Wales as they kept alive their RBS 6 Nations title hopes at Murrayfield.
Wings Tommy Seymour and Tim Visser scored second-half tries, while 19 points from fly-half Finn Russell saw Scotland home 29-13 as they posted a first victory over Wales since 2007.
For a full report and highlights, visit ITV's dedicated 6 Nations website