George North is set to miss Wales' entire autumn series after sustaining a knee injury in Northampton's Champions Cup defeat by Saracens on Sunday.
North has been ruled out for a minimum of six weeks, preventing him from featuring in the fixtures against Australia, Georgia, New Zealand and South Africa that begin at the Principality Stadium on November 11.
"George North suffered a sprain to his posterior cruciate ligament against Saracens which will require 6-8 weeks rehabilitation," a statement issued by Northampton said.
North was initially hurt during a tackle by Brad Barritt and after receiving treatment from Saints' medical team he attempted to run the injury off.
However, the giant wing collapsed shortly after as he looked to hit his stride in order to join a backs move in the club's record defeat at Franklin's Gardens.
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Cardiff Blues and Wales star Sam Warburton is to undergo surgery following the recurrence of a long-standing neck injury.
The Blues said that former Wales skipper Warburton, who captained the British and Irish Lions in New Zealand this summer, faces up to four months out.
It means that Warburton will miss Wales' autumn Tests against Australia, Georgia, New Zealand and South Africa.