Manchester United captain Wayne Rooney has been ruled out of this week's Champions League clash with PSV Eindhoven.
Rooney missed the 3-1 win over Liverpool on Saturday with a hamstring injury and has not recovered in time to travel to Netherlands.
The England captain's absence could mean Marouane Fellaini is once again forced to play upfront, with Anthony Martial and James Wilson also in the squad.
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Wayne Rooney will be presented with an award next month if he breaks or equals England's scoring record in the coming days.
With England facing minnows San Marino on Saturday and then taking on Switzerland at home three days later, Rooney stands a good chance of breaking Sir Bobby Charlton's all-time scoring record over the next week.
The England captain's current total stands at 48 goals, just one shy of the World Cup winning former Manchester United forward.
The Football Association (FA) does not plan to honour the striker until next month, however, as it does not want to be too presumptuous on the matter.
It is understood that the FA instead plans to honour the Manchester United forward with some kind of trophy or plaque before England's next home game against Estonia on October 9.
Wayne Rooney may be failing to fire in front of goal but at least he is having a positive impact on Memphis Depay's development at Manchester United.
Rooney stretched his goalless scoring streak to ten United matches on Saturday as Louis van Gaal's men drew 0-0 at home to Newcastle.
The United captain has not scored since April 4 although he was perhaps unlucky to have one chalked off for a very tight offside call against the Magpies on Saturday.
Yet despite his troubles in the box, Rooney is having a big influence in other areas - most notably in helping Depay find his feet at Old Trafford following his £25m move from PSV Eindhoven.
"Wayne Rooney helps me a lot," Depay said. "He has a lot of experience. He already knows everything about the football world so if I have any questions I can ask him."