NFL commissioner Roger Goodell has said it is a "realistic possibility" that there will be a UK-based franchise if the sport continues to grow in Britain.
For the third successive year, the 2016 season will see three games hosted in the capital, with Twickenham joining Wembley in staging International Series fixtures outside of the United States.
Speaking at a press conference in San Francisco ahead of Sunday's Super Bowl 50, Goodell said he expects more games to be taken to London and did not rule out the possibility of a team one day being based on British soil.
"We are considering playing more games in the UK, it's a balancing act with our schedule," he said.
"As you know, we're playing in two stadiums next year and that gives us a little bit more flexibility of how to do that. I believe the future will see more games in the UK.
"As far as a franchise, let's continue to grow, to see that excitement, enthusiasm, passion and support continue to develop. If it does, I think that's a realistic possibility."
Eminem has become the first rapper to perform a headline show at London's Wembley Stadium.
His two-date set on Thursday and Friday nights is the first time the Lose Yourself star has played a gig in London since 2001.
The 41-year-old, whose hits include Stan and Real Slim Shady, scheduled the shows after an outdoor performance at Hyde Park this year fell through.
Borussia Dortmund have received more than half a million ticket applications for the Champions League final against Bayern Munich, the Bundesliga club said.
Dortmund, who have an average home attendance of around 80,000, said 502,567 fans had applied for tickets online before Sunday's deadline.
"It's absolutely crazy," said the club, adding that a draw would be made to determine who would get the 24,042 tickets the club has been allocated for the match on May 25.
The two finalists have been allocated a total of nearly 50,000 tickets for the final at London's Wembley Stadium, even though the total capacity will be 86,000.