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West Ham duo Winston Reid and Victor Moses have been ruled out until the new year with hamstring injuries.
Defender Reid was injured in training on Wednesday and could be set for a long spell out, with the results of a scan expected on Friday.
On-loan Chelsea winger Moses picked up his injury against Manchester United last weekend and manager Slaven Bilic has ruled him out for four to six weeks.
They are the latest additions to a growing casualty list at Upton Park which threatens to derail their fine start to the season.
The Hammers have already lost Dimitri Payet and Diafra Sakho until February while Manuel Lanzini is out for six weeks with a thigh problem suffered in training.
Enner Valencia has been out for five weeks with an ankle injury but he could give Bilic a boost by being added to the squad to face Stoke on Saturday.
West Ham striker Diafra Sakho will be out for "approximately three months" after surgery on his thigh, the Barclays Premier League club have announced.
The Senegal international suffered the problem as he attempted to shoot during the second half of last Sunday's 1-1 draw with West Brom.
The Hammers are still awaiting the results of a scan to determine the full extent of the injury.
But manager Slaven Bilic said:
It's not good. It will be four to eight weeks. Maybe more.
He has a bit of history with his thigh. It's a muscle injury. Nothing long term, but we will be without him for a few games, definitely.
The injury to Sakho, who has hit five goals this season, is the latest blow to hit Bilic's attacking players after Dimitri Payet and Enner Valencia were sidelined by ankle problems.
Andy Carroll, only recently back to fitness after six months out following ankle surgery, is set to lead the line against Manchester United on Saturday.
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