Scientists and volunteers in Newcastle will carry out a study to discover if a low calorie diet can reverse type 2 diabetes.
The condition affects 3.5 million people in the UK and is often linked to being overweight.
In 2011, a Newcastle University study found that a strict low calorie diet reduced fat levels in the pancreas and liver. As a result, 7 out of the 11 people studied were free from diabetes three months later.
Now, the charity Diabetes UK is funding a larger scale trial. It will involve people across Tyneside who have been diagnosed with type 2 diabetes in the past six years. They will be required to follow a diet of 800 calories a day for a number of weeks.
The man leading the project at Newcastle University described it as 'potentially huge' but acknowledges the regime may not be for everyone.
Diabetes UK said that if successful, the research could be a 'game changer' but it warned the diet would not be a quick fix.
People will be recruited for the trial through GP practices on Tyneside.
Watch a full report on the trial from Helen Ford: