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The Sunderland branch of BHS closes its doors for the final time today.
The struggling retailer filed for administration April but no buyers came forward.
Newcastle United owner Mike Ashley was at one point interested in trying to save parts of the business.
The BHS stores in Hartlepool and South Shields have already closed.
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This is great news not just for the local area but for Britain in general and I am delighted with the firm's view that despite Brexit the country remains an attractive location.
There was such doom-mongering about the economic future of the UK before the Referendum vote but already we are seeing that the fears were exaggerated beyond belief and the GSK investment decision demonstrates this."
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Two BHS stores are set to close in the region for the last time this weekend.
The store in Hartlepool's Middleton Grange Shopping Centre will close its doors today, as well as the store in South Shields' Waterloo Square.
The two North-East locations are part of 20 national closures happening this weekend, affecting 580 BHS employees.
Councillor Kevin Cranney, Hartlepool Council's chair of Regeneration Services Committee, said:
It is a hugely disappointing to see BHS close and our thoughts are with the staff affected and their families.
As a Council we will help in whatever way we can to help and support staff through this difficult period.
There are a number of ways in which the Council can help whether its support to get back into work, setting up your own business, re-training as well as benefit advice.