Parents with children at schools across the Tees Valley are set to receive letters and consent forms over the next few days urging them to take up the offer of the MMR vaccination.
The move follows an outbreak of measles across the North East and is being carried out by the Tees Outbreak Control team.
The team are now introducing a school-based MMR vaccination campaign - to be offered to all children who have yet to be vaccinated against the illness.
The vaccinations will take place across the next few weeks.
"Measles is a highly infectious disease and people can feel very poorly when they have contracted it. 17 per cent of the current cases have required hospital treatment and the disease can lead to rare yet serious complications.
"I would therefore urge all parents to get their child vaccinated through the school based campaign if they have not been immunised already.
"MMR is a safe and highly effective vaccination which protects against measles as well as mumps and rubella."
– Professor Peter Kelly, Chair of the Tees Outbreak Control Team and Director of Public Health at Stockton Council
"I'm very pleased and reassured to see arrangements between the local authorities, NHS England, Public Health North East and the School Nursing Teams working effectively to tackle this outbreak.
"I would like to urge all parents to listen to Professor Kelly's message and make sure their children are vaccinated."
– Councillor Jim Beall, Stockton Council's Cabinet Member for Adult Services and Health
A global scare sparked by the "discredited and inaccurate" claims of a doctor 15 years ago over the MMR vaccine have caused huge worry to parents in South Wales following a measles epidemic in the region, Health Secretary Jeremy Hunt said.
Mr Hunt said Dr Andrew Wakefield's comments about the vaccination had "absolutely no scientific basis" as he urged parents of children who had not been given two doses to contact their local GP as soon as possible.
Mr Hunt told the Commons, "What Andrew Wakefield said had absolutely no scientific basis and has caused huge damage and huge worry to many thousands of parents".
"It is very important to reiterate that the scientific way to prevent measles, which can be a horrible, even fatal disease, is to make sure that you have had two doses of MMR", he continued.
"Parents of children who have not had those doses, parents of children of any age, should contact their GP if they have not had those two doses, particularly in the current circumstances".