The Church of England has voted in favour of allowing women bishops for the first time in its history.
The result means women bishops could potentially be appointed by the end of the year.
After almost five hours of debate, the legislation to allow women to take up senior roles in the church received the required two thirds majority in all three Houses of the General Synod.
Thirty-seven bishops voted in favour with two against and one abstention, while 162 clergy approved with 25 against and four abstentions.
In the House of Laity, there were 152 votes in favour, 45 against and five abstentions.
Two General Synod members on opposite sides of the argument, Christina Rees and Lorna Ashworth, tell ITV News correspondent Tim Ewart why they are adamantly for or against the introduction of women bishops.
David Cameron said he was in favour of women bishops as the Church of England prepares for a second vote on the issue.
The Prime Minister said: "I am in favour of women bishops. I think Archbishop Welby has shown great leadership on this issue and I wish him well."
The Reverend Jody Stowell, from north west London, and a spokeswoman for Women and the Church, said they were "hopeful" of success in the vote for women bishops.
The Church of England is being given a second chance to back the introduction of women bishops at a key meeting today.
– Reverend Jody Stowell
We are hopeful because of all the work that has been done within the General Synod in terms of relationships between people who have different opinions on this.
We would not say we are overly confident at all because it is the same set of people who voted it down in November 2012 so we have to be realistic about that.
The long-running battle over women bishops comes to a head today. Members of the General Synod will cast their final vote at York University. Two years ago, legislation to allow women to become bishops narrowly missed being voted through - prompting complaints from the Bishop of Lincoln.
Ordaining women bishops "will bring hope" to the Church of England after years of debate over the issue, a female Reverend has told Good Morning Britain.
Rev Yvonne Clarke admitted "there may be some division" if the vote went in favour of female bishops but felt, in the long run, "it can only be better for the Church of England".
The Church of England will decide whether or not to back the introduction of women bishops at a meeting in York today.
Members of the General Synod will be asked to give final approval to legislation introducing women bishops in a gathering at York University. If the bill is passed, the first women bishops could be introduced to the Church of England by early next year.
The vote comes after the plan was derailed by just six votes cast by lay members in November 2012, causing shock and bitter recriminations within the Church of England and prompting threats of an intervention by Parliament.