The A19 is closed Southbound because of a lorry fire between the A179 and the B1280 (Sheraton) and Coal Lane (Elwick).
Five people have been taken to hospital following a three vehicle crash on the A19 Northbound that happened this lunchtime.
It was originally thought that the crash involved four vehicles.
A man, a woman and an 8-year-old girl were taken to the RVI in Newcastle RVI and a further two men were taken to South Tyneside District General Hospital.
The 8-year-old girl was airlifted to hospital as a precaution, although her injuries are not believed to be serious.
One man suffered a broken collar bone and the other people involved suffered minor whiplash injuries.
Two small dogs, believed to be terriers, also escaped from one of the vehicles during the collision and have not yet been found.
Anyone with any information should contact Northumbria Police on 101.
The family of a lorry driver who was killed in a crash on the A19 was due to be married in August next year. Andrew Nimmo, 24, died in a collision between two lorries and a car. Another lorry driver, aged 25, has been arrested on suspicion of causing death by dangerous driving.
Police have released the name of a lorry driver who was killed in a crash between two lorries and a car on the A19 on Tuesday morning. Andrew Nimmo, 24, from Murton near Seaham, was due to be married.
Cleveland Police has confirmed that one man has died in the collision on the A19 and two others are seriously injured.
The A19 may remain closed until mid-afternoon.
Severe crash involving two lorries and a car on the A19 between Acklam and the Parkway. The road is closed in both directions.
The A19 is now closed in both directions between the junctions with the A1130 and the A174, due to a serious accident. It is expected to reopen at 9.45am.
The A19 southbound is closed between the junctions with the A1130 and the A174, due to a serious accident. It is expected to reopen at 9.45am.
The A19 northbound near Seaton Burn roundabout is closed after a crash involving four vehicles.
Police were alerted about 11:55am today, August 3. Those involved suffered minor injures.