Ross Smith, from NECC, said: "We'd like to see some better connections into our ports in particular and we think that there's a road scheme on the A1 in North Yorkshire which would better connect us into markets elsewhere in the UK.
"But perhaps one of the biggest things is getting more flights into and out of this region, particularly to the United States and some changes around tax and regulation on aviation could really assist with that."
There might be snow on the ground, and just three weeks until Christmas, but the Chancellor will deliver his Autumn Statement tomorrow lunchtime.
Businesses are hoping the festive spirit may have got to him, as they look for early Christmas presents to boost their firms.
The North East Chamber of Commerce is calling for investment in big infrastructure projects, including upgrading the A1 in North Yorkshire. It also wants more help for businesses to get ambitious plans off the ground.
There is also support for the idea of a government-backed 'Business Bank' to boost lending to small companies.
We spoke to members of the ITV Business Club to find out what's on their Christmas list for the Chancellor.