More than 4,000 runners will gather at Newcastle's Bigg Market to run the 5.9miles of the traditional Blaydon Race.
A number of roads across the route will be closed this evening and motorists are advised to avoid Newcastle, Scotswood and Gateshead where possible.
A church service is taking place at St Nicholas Cathedral in Newcastle to mark the 150th anniversary of the Blaydon Races. The annual run through the city is inspired by the famous Blaydon Races song, which has become a Geordie anthem.
In a service at 1pm, the congregation will perform the song and Bishop Frank White, the assistant bishop of Newcastle, will offer a blessing. The race itself sets off at 6pm.
Karen Boswell, Managing Director of East Coast unveils the newly named "Blaydon Races" electric locomotive with "Queen of the Blaydon Races" Sheila Shorrick-Dodds.
Former England and Newcastle United player Alan Shearer also took part in the naming ceremony at Newcastle Central Station.
The newly named "Blaydon Races" departs Newcastle Central Station for the first time.
A ceremony is taking place for a new East Coast train which is being named after the famous Blaydon Races.
Our reporter Richard Salkeld is at Newcastle Central Station.