Competitors, volunteers and spectators will stand in silence at the start of Sunday's Marathon of the North, to remember the victims of the Boston bombings.
The tribute was announced by the event founder and organiser Steve Cram.
He said the race safety plan has been reviewed in the light of the Boston attacks as the security of participants is paramount but said he didn't anticipate problems.
Watch Helen Ford's report here:
Olympic gold medalist Steve Cram has been speaking to ITV News about how the organisers of the Marathon of the North, and those taking part, will be paying tribute to the victims of the Boston bombings this weekend.
Organisers of the Marathon of the North have been paying tribute to the runners and supporters who lost their lives and were injured in the bombings at the Boston Marathon.
A minute's silence is due to take place before the start of the Marathon of the North on Sunday as organisers and participants pay their respects to victims of the Boston Marathon bombings.
5000 runners are expected to line up for the event, which is in its second year.
The Marathon of the North will take place a fortnight after bombs exploded near the finish line of the Boston Marathon, killing three people.
Sedgefield Harrier Ean Parsons says he has had a lucky escape after completing the Boston Marathon just minutes before two bombs exploded at the finish line, killing two people and injuring many more.
53 year old Ean said, "There was a huge explosion and then 30 seconds later we heard a quieter one, but we were told it was actually bigger than the first. You think to yourself, 'Is it a gas explosion or is it a bomb?'
"As I was approaching the finish line, I remember thinking, 'I'll only be here once,' so I was taking in everything. I remember seeing all the people cheering on the grandstand.
"Then when I later watched the coverage on the television I saw the grandstand blown to bits. I can still remember the faces of the people who were sitting there just hours earlier."