The owners of Durham Tees Valley airport have announced there will be no more dedicated chartered holiday flights from the site.
From 2014, the airport will concentrate on its more profitable business flights.
"Whilst I understand the reasons behind the Company's plans, I very much regret the loss of jobs and holiday flights both of which will affect people throughout the Tees Valley and beyond.
"The challenges facing the airport, which has been losing vast sums of money for several years, are well documented and it is important DTVA plays to its strengths, further developing scheduled flights and exploiting the niche markets identified.
"I hope these radical plans will provide business people and other travellers with even better facilities to help them connect to places across the world."
My Cunningham added, though, that MPs and others will be watching closely to ensure the airport delivers on their plan.
As part of the change, the terminal will undergo changes that will see the operational area smaller to make it more suited to customers on business flights.
New shops and business services will also be incorporated in the new layout.
Steve Gill, managing director of the airport, said: "We have taken these steps following a difficult period for the airport and a thorough review of the whole site and our current operations in order to give the airport a strong foundation to help safeguard the future of the aviation activity.
"The result is a strategic Master Plan which will be available for public consultation from mid November. This will show how we plan to reposition the airport to focus on the business and general aviation and will outline our plans for further developments.
"These will enable us to work towards expanding and diversifying our aviation and non-aviation activities across a broader base and grow back passenger services.
"This is envisaged to provide additional UK and global connections for the region’s business community who have a significant need to access international markets."
He added that recent investment in new hangar facilities and a development site demonstrates their long-term commitment to the airport and Teesside.
Durham Tees Valley airport have announced they are "moving away" from mainstream holiday charter programmes from summer 2014.
Tour operators affected are Thompson/First Choice and Balkan Holidays.
Flights to Schipol in Amsterdam, operated by KLM, and Aberdeen, operated by Eastern Airways, will not be affected.
Flybe flights operated on behalf of CITS to Jersey will also remain in place.
Anyone who has booked holiday flights to Palma, Ibiza or Bulgaria for 2014 flying from Durham Tees Valley Airport is advised to contact their tour operator or travel agent for advice.
Travel expert Simon Calder says once passengers have been to airports like Newcastle, Bradford and Manchester, it is difficult to lure them back.
Durham Tees Valley Airport is to make an announcement about its future later today. It follows yesterdays announcement that Thomson and First Choice had been told they wouldn't be able to operate flights from the airport next year.
Two charter flight operators are pulling out of Durham Tees Valley airport from next year after the airport's owners told them they can no longer operate from the site.
A spokesman for the airport said people who have already booked their seats will fly from another airport.
Thomson and First Choice will no longer be running flights from Durham Tees Valley Airport. They have given the following advice to customers:
"We can confirm that there will be no flights to Palma and Ibiza operated by Thomson Holidays from Durham Tees Valley Airport for the summer 2014 season. For alternative flights to these destinations customers are asked to consult the Thomson website. Further information on the future business direction of the airport will be announced shortly."
Following the news that Thomson and First Choice will no longer provide flights from Tees Valley Airport, Thomson has released this statement:
"Following a business review of operations by Durham Tees Valley Airport, Thomson and First Choice have been notified that they will no longer be able to operate their flights from the airport.
"We have therefore suspended flights from Durham Tees Valley Airport for Summer 2014. We would like to reassure those customers who have already booked holidays departing from Durham Tees Valley that they will be offered an alternative choice of airport.
Our customers are our number one priority and we apologise for any inconvenience caused by this change that is beyond our control. "
Thomson and First Choice will no longer be able to operate flights from Durham Tees Valley Airport.