James Ramsbotham, Chief Executive of the North East Chamber of Commerce, says companies like Nissan need to know whether the UK will remain in the EU.
The head of the Japanese car company, Carlos Ghosn, has claimed they would "reconsider" their position if the UK left the EU.
This would threaten jobs at Nissan's plant in Sunderland, which employs 6,500 people.
Neil Foster, Northern TUC, has said that the region's economy would be left shaken if Nissan left the UK. It comes after the chief executive of Nissan said he would reconsider the car maker's future in the UK if it left the European Union.
Fiona Hall, Liberal Democrat MEP for the North East, has given her reaction to the warning from Nissan about European Union membership.
Nissan's chief executive said he would 'reconsider' the company's future in the UK if it left the EU. The car manufacturer employs 6.500 people in the North East.
Nissan has released a statement after its chief executive said he would "reconsider" the car maker's future in the UK if it left the European Union.
The new Qashqai model will be built at Nissan's Sunderland site, which employs 6,500 workers.
The head of Nissan has said he would "reconsider" the car maker's future in the UK if it left the European Union.
Carlos Ghosn, chief executive of the Japanese motoring company, says he will re-evaluate Nissan's position if the UK leaves the EU.
Speaking at the launch of Nissan's new Qashqai model, he said: "If anything has to change we (would) need to reconsider our strategy and our investments for the future."
He added that an exit is unlikely.
The new Qashqai will be built at Nissan's Sunderland site, which employs 6,500 workers.
A convicted triple murderer from Hartlepool has become the first person in Britain to launch an appeal to the European Court.
Arthur Hutchinson is claiming that the whole-of-life sentence he received is a breach of his human rights.
Hutchinson is behind bars for the murder of a couple and their son in 1983.
Now judges in Europe have ruled that sentences that mean offenders will die in jail are inhuman. But the appeal has caused widespread criticism.
Frances Read reports.
A triple murderer, originally from Hartlepool, has launched a legal challenge against spending the rest of his life in prison.
Arthur Hutchinson stabbed a wealthy couple and their son to death after breaking into their home in 1985.
He is now attempting to have his sentence declared a breach of his human rights.
Hutchinson's appeal come after an EU ruling said a tariff forcing murderers to die in jail was "inhuman and degrading."
Justice Secretary Chris Grayling has said he profoundly disagrees with a recent ruling by the European Court of Human Rights that 'whole life' sentences are "inhuman".
Relatives of the victims of the convicted murderer Arthur Hutchinson have said they are confident his attempt to get his 'whole life' sentence reduced will fail in court.
Hutchinson has launched a challenge against his tariff after the European Court of Human Rights (ECHR) ruled that such sentences are "inhuman and degrading".