Northumbria Police are appealing for witnesses after a black Ford Focus overturned on the northbound carriageway of the A1 Western bypass near Kenton.
The car collided with the nearside verge where it overturned. A woman and three men who were in the car were taken to hospital with minor injuries.
The accident happened shortly before 9 o'clock on Saturday evening.
Police would like to hear from the driver of a light coloured people carrier who may have witnessed the crash. Anyone with information is asked to contact Northumbria Police.