The North East Chamber of Commerce say there are a "significant number of members worried about leaving" the EU.
They went on to say that they want to secure the best possible ongoing relationship with Europe.
“A significant number of our members are worried about the impact of leaving. The focus for us now is to ensure these business concerns are addressed. It is vital the Government ensures minimal disruption to trade and investment as the process of change begins.
“We also need to see measures to reassure businesses on issues such as access to overseas talent and the future of regional funding streams.
“We have an export record which is the strongest in the whole country and this must not be compromised as the decision to leave becomes a reality. The Government must now secure the best possible ongoing relationship with Europe and the rest of the world to enable sustained business growth in our region.”
James Ramsbotham, Chief Executive, the Chamber
The region’s largest business organisation has welcomed measures announced in today’s Autumn Statement, but says the Chancellor must deliver more.
The North East Chamber of Commerce's Chief Executive, James Ramsbotham, says one of the positives for our region is a freeze on business rates at 2 percent.
James Ramsbotham from the North East Chamber of Commerce says it is "extremely embarrassing" that the A1 was forced to close for several days as a result of flooding.
Speaking to ITV Tyne Tees, he said businesses in the region have been resourceful in finding alternative ways to trade but the A1 closure would be costly.