A collision involving a coach and a car happened ay 11am on the A19 near Seaham in County Durham.
Police have confirmed casualties, but the number is not known at this time.
The A19 has been closed to allow an air ambulance to land on the road.
Other ambulance crews, firefighters and the police are at the scene, near to the A1018 turn-off to Ryhope.
A 44-year-old man is fighting for his life at Newcastle's Royal Victoria Infirmary after falling from a bicycle in Dalton-le-Dale near Seaham.
The Great North Air Ambulance Service was called after a man sustained serious head and back injuries. He was placed into a medically induced coma and arrived at hospital in a critical condition.
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The A19 is blocked going north in County Durham, following an accident.
Three vehicles were involved in the crash between Peterlee and Seaham.
It means that that there is also congestion to the B1320 Burnhope Way/Mill Hill.
A teenager from County Durham is one of two people who died in separate incidents at the T in the Park festival in Scotland.
Megan Bell, 17, from Seaham, died at the festival held at Strathallan Castle in Perthshire, along with a 17-year-old boy from west Scotland.
The two deaths are thought to be unrelated and are not being treated as suspicious.
Miss Bell's family have been informed and the teenager is expected to be formally identified on Monday, Police Scotland confirmed.
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A Seaham hotel already undergoing demolition has partially collapsed.
The Harbour View Hotel at 18 North Terrace, Seaham, partly collapsed onto the street on Saturday morning. Police say nobody was inside and nobody was injured in the incident.
Council teams are on site waiting for demolition teams to access the site.
The road remains closed.
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A seafront hotel in Seaham was engulfed by flames during the night. The Harbour View Hotel was unoccupied and no-one was hurt. The building has partially collapsed onto the pavement and road. Durham Police say North Terrace will remain closed this morning.
A woman has been taken to hospital and two men were rescued by neighbours after a fire at a house in County Durham.
Firefighters were called to Melrose Crescent in Seaham just after midnight, June 21.
Crews rescued the woman, who was taken to hospital by ambulance.
The fire service says two neighbours used a ladder to free two men who were upstairs.
A joint police and fire investigation is now underway.