A 58 year old man is in hospital with serious injuries after a crash on the A69.
His car collided with a heavy goods vehicle between Hexham and Haydon Bridge at 2.30 pm.
The Road is expected to remain closed both ways until around seven o'clock this evening.
Diversions are in place.
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Some roads and railways likely to be affected, and motorists are urged to take care on untreated roads