300 temporary workers will finish their final shifts at the Caterpillar factory in Peterlee.
The company's blaming the cuts on the world-wide recession and a lower demand than expected for its trucks.
Unions say they're disappointed.
It leaves about a thousand workers at the site.
More top news
Within the next few weeks security and compounds will arrive at the Monks Cross site for construction work to start.
Newcastle's Freeman Hospital is the first in the region to introduce live music to intensive care, as an aid to recovery
Trading Standards went to the house after a tip-off from someone who had spotted them advertised on social media.