300 temporary workers will finish their final shifts at the Caterpillar factory in Peterlee.
The company's blaming the cuts on the world-wide recession and a lower demand than expected for its trucks.
Unions say they're disappointed.
It leaves about a thousand workers at the site.
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The masterplan for Aykley Heads - home to Atom Bank and Salvus House - will now progress and a delivery model will follow later this year.
The ECB said it "would not be fair, reasonable or proportionate" for Stokes to remain unavailable.
A derailed freight train is causing serious disruption. Network Rail says it is currently mobilising specialist teams.