The NHS is launching a major campaign in the region to encourage more people to give blood.
The number of regular donors has been falling consistently for a decade and doctors say they need 100,000 people to come forward in the next 100 days to address the shortfall.
Sixteen-year-old Christie Dalgleish from Carlisle is only alive today because of seventy tranfusions she received after developing aplastic anaemia three years ago.
Her mother, Jennifer Dalgliesh, says that the importance of people giving blood cannot be overstated.
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Laura Pidcock was among those to raise the issue at Prime Minister's Questions.