A Remploy packaging factory in Sunderland is at risk of closure.
The government has announced 875 compulsory redundancies at Remploy factories across the country - including at the factory based in Sunderland.
Ministers announced earlier this year that a number of Remploy factories would close, arguing that the budget for disabled employment services could be spent more effectively.
Workers at risk of redundancy are in 15 Remploy factories in total.
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They say local churches have already responded and will continue to pray, offer pastoral care and assist those affected.