Blood donors who are O Rh negative (O-) are being asked to come forward to give blood now following the festive period.
The NHS says blood stocks can often dip around holiday time as people get distracted and can't always attend their sessions.
In addition, the recent outbreak of norovirus, has led to an increase in the number of people correctly cancelling their appointments (non-attendance by O-neg donors increased by 50% just before New Year according to NHS figures).
Although hospitals across the country have increased their stocks of blood to cover the extended holiday period, there has been a recent high demand for O- blood to meet patient need, meaning stocks have fallen.
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