Customer services and call centres generate more than 150 million pounds a year for Sunderland's economy.
Representatives from Barclays, npower, 2Touch, and UKAR are among those who will be attending the event.
Jill Hendry says that the event has changed her life.
She was among the 750 who visited last year and has since started a job.
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The body of toddler Norma Dale was found dumped on wasteland near her home in 1946 with one of her red shoes missing.
The full race route, including the start and finish locations, will be unveiled in December
A legacy helped to fund the £700,000 truck