Schools will compete against each other to see who can raise the most money for a hospital unit in Newcastle.
The Bubble Unit is running the challenge and, as Denise Roberts explains, all of the money raised by the nine schools taking part will go towards funding research for the Bubble Foundation UK.
More top news
Sir Tom will be joined on the panel by Oscar-winning actress and singer Jennifer Hudson and rock star Gavin Rossdale.
A new study claims that speech will become our main way of interacting with machines and that will impact the way we talk.
A night of high drama at St James Park saw Newcastle United haul themselves back into the promotion race.