The A174 Parkway eastbound is closed - queueing traffic due to an accident involving a bus, a lorry, a van and three cars between the A19 roundabout and the A1044 Low Lane.
It is causing congestion on the A19 northbound to the A67 (Crathorne).
The road is closed towards Lazenby and is likely to remain closed into this afternoon.
There are also long delays on the Parkway westbound.
More top news
Paul Brand and guests - including two new North East MPs - discuss the Queen's Speech and the Labour/Lib Dem leadership campaigns.
A look ahead at the forecast for the Tyne Tees region.
Health services that dealt with a double murderer should have identified the probability that he would re-offend