The A174 Parkway eastbound is closed - queueing traffic due to an accident involving a bus, a lorry, a van and three cars between the A19 roundabout and the A1044 Low Lane.
It is causing congestion on the A19 northbound to the A67 (Crathorne).
The road is closed towards Lazenby and is likely to remain closed into this afternoon.
There are also long delays on the Parkway westbound.
More top news
Three people have been arrested today after an operation to clear a roadside protest camp.
Five men have appeared in court charged with the murder of a 27-year-old man.
The money raised by the North East Art Collective gallery's charity event in Newcastle will go to the West End Foodbank.