A minute's silence is due to take place before the start of the Marathon of the North on Sunday as organisers and participants pay their respects to victims of the Boston Marathon bombings.
5000 runners are expected to line up for the event, which is in its second year.
The Marathon of the North will take place a fortnight after bombs exploded near the finish line of the Boston Marathon, killing three people.
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GMB's Ben Shephard is cycling, running and swimming from Whitehaven to Tynemouth to raise money for the Children's Heart Unit Fund (CHUF).
Grandfather Stewart Anderson, 54, died after an incident at Durham's Loveshack nightclub in Durham City
The events were part of the work of the Commission for Health and Social Care Integration in the North East.